SLE- Antiphospholipid Syndrome Patho and Treatment

Question 1

APS is a ___________state.

Answer 1

Hypercoagulable/autoimmune

Question 2

What is involved in APS?

Answer 2

Anticardiolipin, lupus anticoagulant

Question 3

Anticardiolipin and lupus anticoagulant can do what?

Answer 3

Create a hypercoagulable state

Question 4

A hypercoagulable state can do what?

Answer 4

Increase risk for a thrombotic event

Question 5

How to get diagnosed with secondary APS

Answer 5

Being aPL(+) and having a thrombotic event

Question 6

Primary APS

Answer 6

APS without lupus or another disease

Question 7

Why is treating APS important?

Answer 7

There are significant morbidity and mortality risks

Question 8

APS is associated with what?

Answer 8

DVTs, stroke, neurologic manifestations

Question 9

APS and pregnancy complications

Answer 9

Unexplained pregnancy loss, premature birth due to eeclampsia, spontaneous abortion

Question 10

APL (+) treatment: aPL (+), no event, and not pregnant

Answer 10

81mg ASA

Question 11

APL (+) treatment: aPL (+), no event, and pregnant

Answer 11

LDA +/- LMWH

Question 12

APL (+) treatment: APS and pregnant

Answer 12

LDA +/- LMWH

Question 13

APL (+) treatment: APS, not pregnant, arterial

Answer 13

warfarin, INR target 3-4

Question 14

APL (+) treatment: APS, not pregnant, venous

Answer 14

warfarin, INR target 2-3