RA- tsDMARDs DI Flashcards

1
Q

tsDMARDs/JAKis drugs

A

Tofacitinib (Xeljanz)
Baricitinib (Olumiant)
Upadacitinib (Rinvoq)

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2
Q

JAKis MoA

A

Inhibit JAK enzymes to block transcription of inflammatory genes

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3
Q

Xeljanz dosing

A

IR: 5mg PO BID
XR: 11mg PO QD

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4
Q

Olumiant dosing

A

2mg PO QD

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5
Q

Rinvoq dosing

A

15mg PO QD

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6
Q

Xeljanz ADEs

A

Increased HDL and LDL
HA
UTI
URTI
GI perforation
Anemia
Neutropenia
Skin cancer
PE
Infections

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7
Q

Olumiant ADEs

A

Increased AST/ALT
Nausea
Herpes zoster and other infections
GI perforation
Thrombosis
Infections

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8
Q

Rinvoq ADEs

A

Increased HDL, LDL, TC, and AST/ALT
Nausea
URTI
Skin cancer
GI perforation
Thrombosis
Anemia
Neutropenia
Infections

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9
Q

JAKis BBW

A

Risk of opportunistic infections, lymphomas, other malignancies, thrombosis (DVT, PE, arterial thrombosis)

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10
Q

What should you screen for before starting a JAKi?

A

Latent TB and Hep B infections

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11
Q

When to use JAKis based on the guidelines

A

Moderate-high disease activity despite DMARD monotherapy

Unable to tolerate/CI to csDMARD

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12
Q

What to use JAKis with

A

Can be used alone or in combination with MTX or other NONBIOLOGIC DMARDs

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