Skin Therapy - Pyoderma Flashcards
Which antibiotics are pseudintermedius resistant to UK?
- penicillin, oxytet highest
- lincomycin, erythromycin, trimethoprim low
- 1% to enrofloxacin and marbofloxacoin
- none to cefalexin, co-amoxiclav, oxacillin, meticillin
> study 1980s, likely increased now
2 methods of antiobiotic choice?
- empirical
- classical superficiial pyoderma/folliculitis = probably s. pseudintermedius
- wet lesions = gram neg?
- local knowledge sensitivity patterns
What are some alternative method of antibacterial tx for superficial pyoderma?
Topical therapy
- antibacterial shampoo (combo or alone)
Clindamycin (Antirobe)
- some resistancre
Most common deep pyoderma organisms?
- rods (pseudomonas) so not b lactams - fluoroquinolones better
- cocci (staph)- cefalexine
Possible reasons for resistance?
> clinical - wrong dose - compliance - absorption - underlying cause - resustance developed during tx > bacteria - intrinsic resistance (natural trait) - acquired resistnace (mutations)
What abx still gets multiresistnat bugs? MRSP
oxytet (but reserve for more serious infections than skin disease!!)
Is MRSP more virulent than normal buugs?
NO
- just more difficult to treat
- may actually be weaker
Which animals are at risk of MRSP infection?
- lots of vet visits and lots of abx use in the past
Is rifampin lic ?
NO
What ROA iss best for gentamycin?
Not systemic (nephrotox)
Can MRSA spread to pets?
YEs
Can MRSP spreadto people?
YES - refer owner to GP if treating animal case
3 tx options for MRSP?
- systemic tx if in vitro susceptability proven (rarely with MRSP, for MRSA most cat/dog strains susceptible to potentialted sulphonamidees and tetracyclines, 50% to clindamycin )
- topical tx alone
- off lic (exotic abx)
Which topical antimicrobial agents have proven efficacy against staph?
- fusidic acid (low MICs shown for MRSA/MRSP)
- chlorhexidine
- benzoyl
Should vancomycin be used?
No!! save for human tx of MRSA