Skin Manifestations of Systemic Disorders Flashcards
Dermatologic manifestations seen with Crohn’s and ulcerative colitis
pyoderma gangrenosum and erythema nodosum
chronic and severely debilitating ulcerative skin disease. Painful hemorrhagic pustule surrounded by erythematous halo
pyoderma gangrenosum
Most common sites for pyoderma gangrenosum
lower extremities, butt, abdomen
Describe lesion that characterizes pyoderma gangrenosum
Irregular, boggy, blue-red ulcers with undetermined borders surrounding a purulent necrotic base
What can you use for high dose systemic corticosteroid treatment of pyoderma gangrenosum?
oral or IV prednisolone 1-2g per day. Can add intralesional triamcinolone
Systemic immunosuppression that can be effective in treating pyoderma gangrenosum
sulfasalazine, cyclosporine, infliximab
Skin condition associated with DM, obesity, internal malignancy (esp. GI)
acanthosis nigricans
Most common sites for acanthosis nigricans
axilla, neck, groin, antecubital fossae
Cutaneous disorder often associated with DM. Lesions are distinctive, sharply dircumscribed, multicolored (red, yellow, brown) plaques occurring on the anterior and lateral surfaces of the lower legs
Necrobiosis Lipoidica (NL), Diabeticorum
Treatment of Necrobiosis Lipoidica (NL), Diabeticorum
Refer. Topical steroids for ulcerations. May need excision and grafting
Self limiting, chronic dermatosis more common in older women characterized by smooth, shiny firm colored papules/plaques that are annular w/central depression
granuloma annular
Most common sites for granuloma annular
dorsum of hands/feet, extremities, and trunk
Percentage of patients with granuloma annular whose symptoms disappear in 2 yrs w/out treatment
75%. Can be treated w/potent topical and intralesional steroids
Usually occurs in areas of increased moisture at the site of infection, DM, or altered systemic immunity. Presents with erythema, tenderness, plaques, possible pruritis
intertrigo
Treatment for intertrigo if found to be caused by fungus
Dry area, wash with benzoyl peroxide or powder with miconazole daily
A candida infection occuring on the mucosa of the upper aerodigestive tract. Associated with HIV, DM, immunosuppression
thrush
Treatment for thrush in a patient with a competant immune system
azoles/imidazoles
Treatment for thrush in a patient who is immunocompromised
oral therapy-fluconazole 2-3 wks
chronic, indolent skin disease associated with Lupus that is characterized by sharply marginated, scaly, atrophic, red (discoid) plaques primarily on face
chronic cutaneous (discoid)
Treatment for chronic cutaneous (discoid) lupus
local corticosteroids, intralesional triamcinolone, and hydroxychloroquine
Occurs in women 15-40 and is characterized by polycyclic scaly plaques in sun exposed areas. also associated with lupus
subacute cutaneous (cutaneous lupus erytheratosus)
Condition characterized by butterfly” facial erythema which is nonscarring, Photosensitivity, Oral ulcers
lupus
treatment for lupus and cutaneous lupus erytheratosus
antimalarials and immunosuppression
Systemic disorder characterized by violaceous (heliotrope) inflammatory changes of the eyelids and periorbital area, photosensitivity, Gattron’s papules
dermatomysitis
