Pharm review

Question 1

First line for scalp fungal infections

Answer 1

griseofulvin

Question 2

First line for nail fungal infections

Answer 2

terbinafine (Lamisil)

Question 3

Duration of therapy for tinea capitis with griseofulvin

Answer 3

8 weeks

Question 4

Administration instruction with griseofulvin

Answer 4

take w/fatty meal to increase absorption and lessen GI upset

Question 5

T/F The smaller the particle size the greater the bioavailability

Answer 5

true

Question 6

Pregnancy category of griseofulvin

Answer 6

X

Question 7

For what allergy do you need to watch for potential cross reactivity when prescribing griseofulvin?

Answer 7

PCN

Question 8

superior for the treatment of infections from Trichophyton species

Answer 8

terbinafine

Question 9

superior for the treatment of infections due to Microsporum

Answer 9

griseofulvin

Question 10

Labs needed prior to administration of terbinafine

Answer 10

AST/ALT and CBC

Question 11

Minimum age needed to be prescribed terbinafine

Answer 11

at least 4 yrs

Question 12

Treatment for failure of terbinafine for onychomycosis

Answer 12

itraconazole (Sporanox)

Question 13

Black box warning of itraconazole (Sporanox) usually associated with IV administration

Answer 13

negative inotropic effects

Question 14

Necessary before prescribing azole antifungals

Answer 14

drug interaction checker

Question 15

First line therapy for the treatment of androgenic alopecia in men

Answer 15

finasteride (propecia)

Question 16

What effect can finasteride have on PSA values?

Answer 16

can reduce them up to 50%. need to draw baseline before initiation of therapy and follow

Question 17

When should you refer a patient on finasteride to urology?

Answer 17

if PSA increases while on medication

Question 18

Treatment of severe, recalcitrant, nodular acne. only prescribed by dermatologist

Answer 18

Isotrentinoin (Accutane)

Question 19

Baseline monitoring before initiation of Accutane

Answer 19

CBC, fasting lipid, LFTs. Repeat every 4 wks

Question 20

How often should a woman on Accutane have a pregnancy test?

Answer 20

monthly during administartion and one month after discontuation of therapy

Question 21

What abnormal lab results are necessary to discontinue Accutane therapy?

Answer 21

TG > 800 and LFTs 3X upper normal limit

Question 22

Minimum age for use of topical calcineurin inhibitors

Answer 22

2 yrs

Question 23

CI for topical calcineruin inhibitors

Answer 23

systemic immune suppressants and immunocompromised patients

Question 24

Common side effect of protopic

Answer 24

skin burning at site of application

Question 25

Patients present with some combination of arthralgia, myalgia, malaise, fever, rash, and/or serositis

Answer 25

drug induced lupus like syndrome

Question 26

Treatment for drug induced lupus like syndrome

Answer 26

discontinuation and NSAIDs. if sx don't resolve within 4-8 wks hydroxychloroquine. if severe, systemic corticosteroids