Dermatopathology Flashcards
Epidermis cell type that can be categorized into the “stratum” layers. Predominant cell of the epidermis
keratinocytes
essential to the protective function of the skin and is the structural protein of hair and nails. produced by keratinocytes
keratin
Name the five layers of the keratiocytes
corneum, lucidum, granulosum, spinosum, germativum
Located at or in the basal layer. Pigment-synthesizing cells (produce melanin)
melenocytes
converts amino acid tyrosine to precursor of melanin. if you lack this enzyme you’re albino.
tyrosinase
Increases production of melanin
UV rays
T/F Dark-skinned and light-skinned people have same amount of melanocytes
true
Least densely populated cells of the epidermis
Function as mechanoreceptors (touch receptors).
Merkel’s cells
Scattered in the suprabasal layer of the epidermis. Immunologic cells responsible for recognizing foreign antigens harmful to the body
Langerhan’s cells
Connective tissue layer separating the epidermis from the subcutaneous fat layer. Mostly composed of collagen
Dermis
Consists primarily of fat and connective tissues that lend support to the vascular and neural structures supplying the dermis and epidermis
subcutanesou tissue
Located over entire body surface, originate in dermis and open directly to the skin surface. transport sweat to body surface to regulate body temperature
Eccrine (merocrine) glands
located in deep dermal layer. Open through a hair follicle. sterile until mixed with bacteria
apocrine glands
Located over the entire skin surface except for palms, soles, and sides of feet. secrete sebum to lubricate hair/skin
sebaceous glands
determine hair color
melanocytes
causes goose bumps
arrector pili muscle
Circumscribed flat lesion < 1cm
macule
Flat lesion > 1cm
patch
Elevated solid lesion with variable color < 0.5cm. May become confluent and become a plaque
papule
Raised flat-topped superficial lesion where diameter is greater than the thickness (>0.5cm)(often formed by coalescence of papules)
plaque
Elevated lesion with a rounded surface (generally deeper and firmer than a papule)(0.5 – 1-2cm)
nodule