Miscellaneous Skin Conditions Flashcards

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1
Q

Hereditary skin condition where cell turnover is reduced to 4 days instead of 27 leading to increase in number of cells produced without normal cell keratinization

A

psoriasis

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2
Q

psoriasis plaques that form at the site of a skin injury 1-2 weeks later

A

Koebner’s phenomenon

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3
Q

Improves psoriasis

A

sun exposure

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4
Q

Pinpoint bleeding under the scale that results from removal

A

Auspitz sign

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5
Q

Patient presents with salmon pink papules/plaques that are sharply marginated w/silvery-white scaling

A

psoriasis

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6
Q

Most common type of psoriasis. Is well defined, symmetrical, appears on knees, scalp, elbows, lower back

A

plaque

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7
Q

Type of psoriasis commonly found in axilla, groin, naval, submammary region, palms, scalp, soles. NO SCALES and more common in overweight persons

A

inverse

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8
Q

Type of psoriasis that occurs in young adults and children. Multiple small teardrop shaped erythematous papules. Scattered diffusely on the proximal extremities and trunk

A

guttate

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9
Q

Most generalized and least common type of psoriasis with erythema and scaling from head-toe. High risk of systemic infection and electrolyte imbalance

A

erythrodermic

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10
Q

Severe form of psoriasis w/life threatening complications. Acute onset with sheets of superficial pustules with erosions. Associated w/fever, diarrhea, leukocytosis, hypocalcemia

A

pustular

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11
Q

The most common precipitating factors for erythrodermic or pustular psoriasis

A

acute withdrawal of systemic corticosteroids

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12
Q

Useful in all cases of psoriasis. Hydrates stratum corneum and decreases water evaporation. Softens scales

A

emollients- eucerin, lubriderm, moisturel applied while skin is still damp

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13
Q

first line agents for mild/limited plaque psoriasis.

A

topical steroids

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14
Q

Used as add-on therapy with topical steroids for treating psoriasis. Enhances effects of UVB therapy

A

coal tar

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15
Q

VItamin D analog used in mild to moderate plaque psoriasis as an immune modulator. Side effects include hypercalcemia and hypercalciuria when topical doses exceed 100g/wk

A

Calcipotriol (Dovonex)

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16
Q

Less effective than Calcipotriene but much fewer side effects including fewer changes in systemic calcium metabolism

A

Calcitriol (Rocaltrol)

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17
Q

Areas you cannot use calcipotriol (Dovonex) due to irritation

A

face and groin

18
Q

Systemic therapies only indicated for severe or incapacitating psoriasis or with topical treatment failure

A

PUVA, methotrexate, retinoid, cyclosporine

19
Q

What do the following have in common: Beta-blockers, NSAIDs, lithium, ACEI, digoxin?

A

drugs that may exacerbate psoriasis

20
Q

Immune mediated skin eruption of well-circumscribed wheals on an erythematous base. IgE mediated

A

Urticaria (hives)

21
Q

Hypersensitivity reaction involving the deep layers of the skin. Swelling of the lips, eyelids, palms, soles, genitalia

A

angioedema

22
Q

Patient presents with edematous, erythematous, well circumscribed blanching wheals with serpiginous borders

A

urticaria

23
Q

Substances that may aggravate urticaria and angioedema

A

ASA, NSAIDs, ETOH, ACEI

24
Q

Initial treatment for urticaria and angioedema

A

H1 blockers (diphenhydramine, fexofenadine)

25
Q

Treatment for urticaria and angioedema refractory to H1 blockers

A

H2 blockers (Ranitidine)

26
Q

reserved after a trial of maximal doses of antihistamines for urticaria and angioedema

A

steroids

27
Q

for severe attacks (anaphylaxis like reactions) of urticaria and angioedema

A

subQ epi

28
Q

What conditions should you consider investigating for patient who presents with urticaria and angioedema?

A

thyroid and H.pylori

29
Q

formation of antibodies to melanocytes. Often occurs in the context of other autoimmune conditions such as pernicious anemia and Hashiomoto’s thyroiditis

A

vitaligo

30
Q

Treatment that can help with repigmentation of vitaligo

A

topical steroids, tacrolimus, psoralens, UVA/UVB

31
Q

potentially fatal disease of the mucous. Intraepidermal blistering secondary to an autoimmune process

A

pemphigus

32
Q

Lesions characteristic of pemphigus that begin in oropharynx and spread to scalp, face, chest, axillae, groin

A

flaccid bullae that are tender and painful

33
Q

Required for diagnosis of pemphigus or bullous pemphigoid

A

biopsy

34
Q

Treatment for pemphigus

A

hospitalization, systemic corticosteroids, immunosuppressives

35
Q

skin finding in which the top layers of the skin slip away from the lower layers when slightly rubbed. associated with pemphigus and TEN

A

Nikolsky sign

36
Q

Chronic, subepidermal blistering autoimmune disease. May possibly be triggered by a drug reaction or infection. Almost exclusively in the elderly population

A

bullous phemphigoid

37
Q

Describe the lesions of bullous pemphigoid

A

tense and fluid filled blisters associated with urticarial plaques

38
Q

1st line treatment for bullous pemphigoid

A

topical high dose or oral steroids

39
Q

Most common cutaneous cyst. Derived from epidermis or epithelium of hair follicle. Becomes filled with keratin and lipid-rich debris

A

epidermoid cyst

40
Q

Very common, button-like dermal nodule

Lesion may be tender and is benign

A

dermatofibroma

41
Q

Benign subcutaneous tumors. Soft, rounded, and movable against the overlying skin.

A

lipoma

42
Q

What is the difference between epidermal and subcutaneous masses?

A

epidermal feel fixed whereas subcutaneous are generally mobile