Skin Immunology

Question 1

which type of immunity has memory?

Answer 1

specific - memory

non-specific - no memory

Question 2

the keratin layer is a physical barrier formed by terminal differentiation of _____________ to ___________.

Answer 2

the keratin layer is a physical barrier formed by terminal differentiation of KERATINOCYTES to CORNEOCYTES.

Question 3

name the 3 important proteins found in the keratin layer/epidermis.

Answer 3

fliggarin
involucrin
keratin

Question 4

what can keratinocytes be activated by?

Answer 4

UV (sunlight)

Question 5

what can keratinocytes produce to kill pathogens?

Answer 5

AMPs (high in those with psoriasis)

Question 6

Langerhans cells are found in the interspace between the keratinocytes and epidermis and are characterised by what granule?

Answer 6

Birbeck granule

Question 7

what type of T cell is found in the epidermis?

Answer 7

CD8+ T

Question 8

what type of T cell is found in the dermis?

Answer 8

CD4+ T and CD8+ T

Question 9

name the CD4+ TH cells associated with the following inflammatory conditions:

(a) psoriasis
(b) atopic dermatitis
(c) psoriasis and atopic dermatitis

Answer 9

(a) psoriasis - TH1
(b) atopic dermatitis - -TH2
(c) psoriasis and atopic dermatitis - TH17

Question 10

name the main cells involved in the following reactions:

(a) type I
(b) type II
(c) type III
(d) type IV

Answer 10

(a) type I - IgE
(b) type II - IgG
(c) type III - IgM
(d) type IV - TH1 cells