Pharmacology Flashcards

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1
Q

rate of diffusion is described by which law?

A

Fick’s Law

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2
Q

name the 4 combinations of drugs and bases

A

lipophilic drug in lipophilic base

lipophilic drug in hydrophilic base

hydrophilic drug in lipophilic base

hydrophilic drug in hydrophilic base

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3
Q

which combination of drug and base is best for preferential partitioning into the skin?

A

lipophilic drug in hydrophilic base

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4
Q

the inclusion of __________ in the vehicle can enhance solubility of a drug

A

excipients

e.g. propylene glycol

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5
Q

the greater the __________ of the skin, the better the ____ __ _________ in the skin of the drug

A

the greater the WATERINESS of the skin, the better the RATE OF DIFFUSION in the skin of the drug

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6
Q

name the 2 factors that influence the absorption of topically applied drugs

A

nature of skin - site hydrations and integrity

drug/pharmaceutical preparation - concentration, salt and vehicle

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7
Q

glucocorticoids signal via _______ receptors (class _)

A

glucocorticoids signal via NUCLEAR receptors (class 1)

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8
Q

drugs can be delivered by what to increase duration and effectiveness and provide a constant rate of delivery?

A

transdermal patches

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9
Q

long term use of high ______ steroids can produce serious ______ effects

A

long term use of high POTENCY steroids can produce serious ADVERSE effects

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10
Q

name some drugs that can be delivered via TDPs.

A

nicotine
GTN
fentanyl
estradiol

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