Pathology - Rash Flashcards
the dermis is composed of which 2 types of collagen?
type 1
type 111
name the pathological terms to describe the following:
- increased thickness of keratin layer
- persistence of nuclei in the keratin layer
- increased thickness of epithelium
- increased thickness of keratin layer - HYPERKERATOSIS
- persistence of nuclei in the keratin layer - PARAKERATOSIS
- increased thickness of epithelium - ACANTHOSIS
irregular epithelial thickening is also known as ______________
irregular epithelial thickening is also known as PAPILLOMATOSIS
oedema fluid between the squames increases the prominence of intercellular prickles describes what?
spongiosis
how many classifications of reaction pattern are there?
4
name the 4 main reaction patterns
- spongiotic-intraepidermal oedema
- psoriasiform-elongation of the rete ridges
- Lichenoid-basal layer damage
- vesiculobullous-blistering
name a disease/condition the is classifies as spongiotic-intraepidermal oedema
eczema
name a disease/condition the is classifies as psoriasiform-elongation of the rete ridges
psoriasis
name a disease/condition the is classifies as Lichenoid-basal layer damage
lichen plants and lupus
name a disease/condition the is classifies as vesiculobullous-blistering
pemphigoid, pemphigus and dermatitis herpetiformis
psoriasis is associated with epidermal ___________ and specific ___ types
psoriasis is associated with epidermal HYPERPASIA and specific HLA types
Lichen planus histology:
- irregular ________ acanthosis
- ______granulosis and ortho______________
- upper dermal _________ infiltrate
- basal damage with ______ ____ formation
Lichen planus histology:
- irregular SAWTOOTH acanthosis
- HYPERgranulosis and orthoHYPERKERATOSIS
- upper dermal LYMPHOCYTE infiltrate
- basal damage with CYTOID BODY formation
_______ lupus resembles lichen planus
DISCOID lupus resembles lichen planus
what is the primary feature in immunobullous diseases?
blisters
name 3 important immunobullous disorders
- pemphigus
- bullous pemphigoid
- dermatitis herpetiformis
pemphigus has _ distinct subtypes but __% of cases is pemphigus ________
pemphigus has 4 distinct subtypes but 80% of cases is pemphigus VULGARIS
pemphigus vulgaris is an __________ condition
pemphigus vulgaris is an AUTOIMMUNE condition
what type of auto-antibody are made against desmoglein 3 in pemphigus vulgaris?
IgG
what is the end result in pemphigus vulgaris?
acantholysis
dermatitis herpetiformis is a ____ condition with a strong association with what disease?
dermatitis herpetiformis is a RARE condition with a strong association with COELIAC DISEASE
dermatitis herpetiformis is associated with ___ haplotype, intensely _____ symmetrical lesions of the _____, ____ and _______
dermatitis herpetiformis is associated with HLA haplotype, intensely ITCHY symmetrical lesions of the ELBOW, KNEE and BUTTOCKS
what is the hallmark of dermatitis herpetiformis?
papillary dermal microabscesses
what antibody is important in dermatitis herpetiformis?
IgA target gliadin generating neutrophil chemotaxis
acne vulgaris:
- _________ androgens at puberty
- increased androgen ___________
- pilosebaceous units become _______
- keratin and sebum _____ up and ruptures causing _____ ___________
acne vulgaris:
- INCREASED androgens at puberty
- increased androgen SENSITIVITY
- pilosebaceous units become PLUGGED
- keratin and sebum BUILD up and ruptures causing ACUTE INFLAMMATION
rosacea is more common in which sex?
female
what is rosacea?
recurrent facial flushing - visible blood vessels and pustules and rhinophyma
what triggers aggravate rosacea?
sunlight
alcohol
spicy foods
stress
rosacea sometimes responds to what?
tetracyclines
rosacea hallmarks:
________ ectasia and pustules
rosacea hallmarks:
VASCULAR ectasia and pustules
rosacea pathology:
perifollicular __________ and follicular ________ mites often noted
rosacea pathology:
perifollicular GRANULOMAS and follicular DERMODEX mites often noted
