Cutaneous Drug Eruptions

Question 1

what type of reaction is ‘urticaria’?

Answer 1

type I - anaphylactic

Question 2

what type of reaction is ‘pemphigus and pemphigoid’?

Answer 2

type 11 - cytotoxic

Question 3

what type of reaction is ‘purpura/rash’?

Answer 3

type III - immune complex mediated

Question 4

what type of reaction is ‘erythema/rash’?

Answer 4

type IV - T-cell mediated

Question 5

immunological mediated reactions are Not dose dependent

true or false?

Answer 5

true

Question 6

name 3 drugs associated with exanthematous drug eruptions

Answer 6

penicillins
erythro/streptomycin
allopurinol

Question 7

name 2 drugs that cause pustular/bullous drug eruptions

Answer 7

glucocorticoids

androgens - lithium etc

Question 8

drug-induced bulls pemphigoid can be caused by what? (3)

Answer 8

ACE inhibitors, penicillin and furosemide

Question 9

Linear IgA disease can be triggered by which drug?

Answer 9

vancomycin

Question 10

name drugs associated with fixed drug eruptions (4)

Answer 10

tetracycline, doxycycline
paracetamol
NSAIDs
carbamazepine

Question 11

name 4 severe cutaneous adverse reactions

Answer 11

SJS - Stevens-Johnson syndrome

TEN - Toxic Epidermal Necrolysis

DRESS - Drug reaction with eosinophilia and systemic symptoms

AGEP - Acute generalised exanthematous pustulosis

Question 12

name some drugs which cause the severe cutaneous adverse reactions

Answer 12

sulfonamide
cephalosporins
carbamazepine
NSAIDs
anticonvulsants
allopurinol

Question 13

name some drugs associated with phytotoxicity

Answer 13

antibiotics
thiazide diuretics
chlorpromazine
NSAIDs
amiodarone

Question 14

what gender is more likely to experience cutaneous drug eruptions?

Answer 14

female

Question 15

what is the most common type of drug eruption?

Answer 15

exanthematous (90%)

Question 16

what drugs are your common culprits of cutaneous eruptions?

Answer 16

NSAIDS
doxycycline
amiodarone
chlorpromazine
quinine

Question 17

what drug mist commonly causes phytotoxicity?

Answer 17

thiazide diuretics

Question 18

telangiectasia & angiomas can occur on sun exposed sites due to which type of drug?

Answer 18

calcium antagonists

Question 19

____ can induce sub-acute cutaneous lupus

Answer 19

PPIs can induce sub-acute cutaneous lupus

Question 20

what can chlorpromazine cause?

Answer 20

golden-brown pigmentation