Skin and Soft Tissue Infections Flashcards
Most SSTI arise from ____
break in physico-chemical barriers
Most SSTIs are caused by what 2 pathogens?
Staph aureus Strep pyogenes (group A strep)
Chronic inflammation suggests _____ route of infection and _____ organisms.
hematogenous
intra-cellular
Acute inflammation activates ___ immunity.Usually caused by ____ bacteria. Immune system activated by ____ PRR/TLRHallmark sign =
Acute inflammation activatesinnateimmunity.
Usually caused by extracelluarbacteria.
Immune system activated by cell surfacePRR/TLR
Hallmark sign =pus (neutrophils)
Chronic inflammation activates ___ immunity.Usually caused by ____ bacteria.Immune system activated by ____ PRR/TLRHallmark sign =
Chronic inflammation activates adaptiveimmunity.
Usually caused by intracellularbacteria.
Immune system activated by intracellularPRR/TLR
Hallmark sign =granuloma
Gram + cocci,Catalase +,Coagulase + bacteria
Staphylococcus aureus
Name 3 other S. aureusskin infections
Impetigo
Toxic Shock Syndrome: TTS-1
Scalded Skin Syndrome: Exfoliative toxin
Strep pyogenesis catalase (+/-) ___ hemolytic, bacitracin (sensitive/insensitive)
Strep pyogenesis catalase +,betahemolytic, bacitracin sensitive
Treatment if pus is present and mild disease (no systemic signs/no co-morbid conditions)
I&D and drainage only
Treatment if pus is present and moderate disease (systemic signs but no evidence of SIRS/immunosuppression)
I and D and drainage
C and S and sensitivity
Treatment if non-purulentand mild disease (no systemic signs, no pururlence or evidence of locaulated collection of material)
Oral penicillin, cephalosporin or clindamycin
Treatment if non-purulent and moderate disease (systemic signs but no evidence of SIRS/immunosuppression)
IV PCN, cephalosporin, or clindamycin
