Ovarian Cancer

Question 1

T/F: Ovarian cancer is the leading cause of death in women.

Answer 1

True

Question 2

T/F: Ovarian cancer is mostly curable.

Answer 2

False. Most arenotcured but patients are living longerwithcancer.

Question 3

T/F: Staging ofOvarian canceris determined by clinical evaluation.

Answer 3

False. Surgically staged

Question 4

Primary method of spread of ovarian cancer

Answer 4

shedding of tumor in intraperitoneal cavity

Rarely lymphatic/blood

Question 5

Most common type of ovarian cancer

Answer 5

Epithelial ovarian cancer
60% of all ovarian neoplasms
80% of malignant ovarian tumors

Question 6

Types of ovarian cancer (3)

Age of onset of each type

Answer 6

Epithelial: 60 y/o
Germ cell: 20-30 y/o
Sex cord stormal: younger women

Question 7

T/F: Epithelial ovarian cancers have a better prognosis than germ cell tumors.

Answer 7

False. Germ cell tumors have better prognosis

Question 8

Most common type of sex cord stormal tumors

Symptoms?

Answer 8

Granulosa cell tumor
Symptoms:
Precocious puberty
Adenomatous hyperplasia (mass)
Vaginal bleeding (postmenopausal women)

Question 9

2 biggest risk factors of ovarian cancer

Answer 9

FHx andAge

Also:

• Nulliparty (having no kids)
• Endometriosis
• Early menarche, late menopause
• Late childbirth (age >35)
• Environmental factors

Question 10

Delay of diagnosis of ovarian cancer isd/t ___

Answer 10

non-specific/vague symptoms

• Increased abdominal girth (ascites)
• Bloating
• Fatigue
• Abdominal pain, back pain, pain w/ sex
• Early satiety
• Indigestion
• Constipation
• Unexplained weight loss
• Urinary frequency or incontinence

Question 11

T/F: HNPCC gene causes an increased risk in ovarian and breastcancer.

Answer 11

False. No increased risk in breast cancer. Increased risk in ovarian cancer.

Question 12

T/F: PAP smear as a moderately effective screening tool for ovarian cancer.

Answer 12

False.PAP smear does NOT screen for ovarian cancer

There is NO truely effective method

Question 13

T/F: AFP is a biomarker blood test used to screen for ovarian cancer.

Answer 13

False. CA125 is used as a non-specific blood test.

Not really that great but not that many options for screening for ovarian cancer

Question 14

T/F:Simultaneous screening w/ CA125 + TVUS reducesovarian cancer mortality

Answer 14

False. It did NOT reduce

Question 15

Which of the following is NOT a finding that suggestssuspicious pelvic mass inpostmenopausalwomen?
A. Ascites
B. Nodular/fixed pelvic mass
C. Evidence of distant metastasis
D. Elevated CA125 > 200
E. FHx of breast/ovarian cancer

Answer 15

D. Elevated CA125 > 35 inpostmenopausalwomen

Elevated CA125 > 200inpremenopausalwomen

Question 16

Treatment of ovarian cancer should be a combination of:

Answer 16

Surger + chemotherapy