simvastatin 6

Question 1

Extreme rare side effect of simvastatin is known as?

Answer 1

Rhabdomyolysis

Question 2

Higher risk of extreme side effect of simvastatin occurs at what dose?

Answer 2

80mg/day dose

Question 3

statin that was voluntarily withdrawn in 2001 due to report of fatal rhabdomyolysis( 52 deaths)

Answer 3

Cerivastatin

Question 4

What is Rhabdomyolysis?

Answer 4

Breakdown of the muscle which can form myoglobin which can cause damage to the kidney leading to kidney failure

Question 5

Simvastatin is metabolized by what enzyme?

Answer 5

Cytochrome P450

CYP3A4
in the liver

Question 6

How does Grapefruit juice interacts with Simvastatin?

Answer 6

GFJ inhibits cytochrome P450 CYP3A4 enzyme and prevents the metabolism of Simvastatin in the liver which causes an overdose of simvastatin which can lead to side effect such as rhabdomyolysis

Question 7

Explain why Pitavastatin is not inhibited by GFJ

Answer 7

Pitavastatin is metabolised by CYP2C9 and so unaffected by GFJ interaction