oxymetazoline 4

Question 1

state Physical properties of oxymetazoline

Answer 1

Oxymetazoline hydrochloride

Stable, white, crystalline solid

Non-hygroscopic

Sparingly soluble in water (1.4 mg/L) and alcohols

Insoluble in diethyl ether, chloroform and benzene

Melting point: 181-183 °C

pKa 11.6 (3 ° imidazoline H) & pKa 10.9 (phenol)

Question 2

_____________ is the active ingredient in a number of decongestant nasal spray (DNS) products

Answer 2

Oxymetazoline

Question 3

list some brand names for oxymetazoline?

Answer 3

Vicks Sinex
Sudafed OM
Afrin (USA)

Question 4

oxymetazoline Provides rapid relief from blocked nose for up to __________

Answer 4

12 hours

Question 5

what is the dose for oxymetazoline?

Answer 5

Doses for adults and children over the age of 12:

1 to 2 sprays in each nostril
Every 6 to 8 hours

Question 6

what’s formulation does oxymetazoline come in?

Answer 6

Nasal Spray

Pump mist, anti-drip:
0.05% (0.5 mg mL-1)

Alternatively, injected
into the vein

Question 7

which excipient has a strong methanol like odour?

Answer 7

Camphor racemic

1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

Question 8

which excipient has a mint like odour?

Answer 8

Eucalyptol (main component, 90%, of eucalyptus oil)

1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane

Question 9

what are the common side effects of

Answer 9

Dryness or irritation of the nasal mucosa
Nausea
Headache
Local burning sensation
Rhinitis medicamentosa
(Rebound congestion)