Metformin 5

Question 1

What is the extremely rare side effect of metformin called?

Answer 1

Lactic acidosis

Question 2

What is lactic acidosis?

Answer 2

conversion of pyruvate to lactate which reduces the uptake of lactic acid by the liver and leads to lowering of the blood pH which causes 25-50 % risk of death

Question 3

Higher risk of Lactic acidosis is with ………?

Answer 3

Phenformin and Buformin

Question 4

list the central symptoms of Acidosis?

Answer 4

1. Headache
2. Sleepiness
3. Coma
4. Confusion
5. Loss of Consciousness

Question 5

Respiratory symptoms of acidosis are?

Answer 5

Shortness of breathe

coughing

Question 6

Muscular symptoms of Acidosis are ?

Answer 6

Muscle weakness

seizure

Question 7

Intestinal symptom of Acidosis is ?

Answer 7

Diarrhoea

Question 8

Gastric symptoms of Acidosis are …….

Answer 8

Nausea

Vomiting

Question 9

Heart symptoms of Acidosis are …..

Answer 9

Arrhythmia

Increased heart rate

Question 10

List other side effects of metformin

Answer 10

GI disturbances - 1 in 10 people
Loss of appetite- 1 in 10
Taste disruptions - 1 in 10 - 1 in 100
Skin rash and itching - 1 in 10,000
Malabsorption of vitamin B12- 1 in 10, 000