oxymetazoline 1 Flashcards

1
Q

what is the use of oxymetazoline?

A

nasal Decongestant. Congestion caused by rhinitis, hay fever, allergies, colds, sinus problems

Nasal inflammation

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2
Q

what is oxymetazoline made of _________?

A

Alkylphenol

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3
Q

when was oxymetazoline developed?

A

Developed by Merck in 1961

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4
Q

how does oxymetazoline work?

A

congestion happens because of Nasal inflammation

Veins & small arteries swell

Restricted airflow

Oxymetazoline Stimulates α-adrenergic receptors in nasal blood vessels

Vasoconstriction in blood vessels

Opens nasal passages

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5
Q

what is an inverse agonist?

A

A chemical that binds to a receptor and induces a pharmacological response opposite to that of the agonist

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6
Q

oxymetazoline is _____________

A

an α-adrenoceptor/ α-adrenergic agonist (agonist for α1 and partial agonist for α2 )

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7
Q

what is α1- & α2-receptors responsible for?

A

increased Smooth muscle contraction↑ vasoconstriction↑

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8
Q

β1-receptors are responsible for _______________

A

increased Heart rate↑ heart muscle contraction↑

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9
Q

β2-receptors is responsible for ____________

A

increased Muscle contraction↑ blood-glucose↑ respiration↑

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10
Q

β3-receptors is responsible for ________

A

increased Lipolysis (using stored energy)↑

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11
Q

Adrenaline and Noradrenaline (neurotransmitters) binds to α- and β-adrenergic receptors (adrenoreceptors), activating them to cause _____________

A

↑ blood flow to muscles
↑ heart rate
↑ blood-glucose level
↑ alertness

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