oxymetazoline 1 Flashcards
what is the use of oxymetazoline?
nasal Decongestant. Congestion caused by rhinitis, hay fever, allergies, colds, sinus problems
Nasal inflammation
what is oxymetazoline made of _________?
Alkylphenol
when was oxymetazoline developed?
Developed by Merck in 1961
how does oxymetazoline work?
congestion happens because of Nasal inflammation
Veins & small arteries swell
Restricted airflow
Oxymetazoline Stimulates α-adrenergic receptors in nasal blood vessels
Vasoconstriction in blood vessels
Opens nasal passages
what is an inverse agonist?
A chemical that binds to a receptor and induces a pharmacological response opposite to that of the agonist
oxymetazoline is _____________
an α-adrenoceptor/ α-adrenergic agonist (agonist for α1 and partial agonist for α2 )
what is α1- & α2-receptors responsible for?
increased Smooth muscle contraction↑ vasoconstriction↑
β1-receptors are responsible for _______________
increased Heart rate↑ heart muscle contraction↑
β2-receptors is responsible for ____________
increased Muscle contraction↑ blood-glucose↑ respiration↑
β3-receptors is responsible for ________
increased Lipolysis (using stored energy)↑
Adrenaline and Noradrenaline (neurotransmitters) binds to α- and β-adrenergic receptors (adrenoreceptors), activating them to cause _____________
↑ blood flow to muscles
↑ heart rate
↑ blood-glucose level
↑ alertness