signal transduction flash Flashcards
1
Q
Questions
A
Answers
2
Q
Growth factor
A
Stimulates cell to leave Go, functions through signal transduction
3
Q
EGF
A
epidermal GF.
4
Q
PDGF
A
platelet derived GF
5
Q
FGF
A
fibroblast GF
6
Q
NGF
A
nerve GF
7
Q
TGT-alpha
A
transforming GF
8
Q
TGF-beta
A
transforming GF. Targets everything
9
Q
raf
A
MAPKKK. Ser/ Thr kinase. Requires ras to become active
10
Q
ras
A
GTP binding protein
11
Q
PKB (Akt)
A
Stimulates cell cycle progression and inhibits apoptosis. GFâ>PI3â>PKB
12
Q
Bcl-2
A
pro and anti-apoptotic
13
Q
BAD
A
pro-apoptotic factor, phosphorylated and inactivated by PKB
14
Q
E2F
A
TF that is inhibited by Rb (regulated by cyclin) to keep TF from transcription of genes to enter S phase
15
Q
p53
A
recognizes damaged DNA and acts as TF to stop cell cyclin by inducing CKI
16
Q
BRCA1
A
Inhibit cell cycle, repair of damaged DNA
