glycogen flash

Question 1

Questions

Answer 1

Answers

Question 2

Glycogen phosphorylase

Answer 2

Degrade glycogen by breaking alpha (1,4) to release G1P. Can work up to 4 residues from alpha (1,6) (dextrin). Requires B6 (pyridoxal phosphate). On same enzyme as debranching enzyme

Question 3

Debranching enzyme

Answer 3

Degrade branch points in glycogen by breaking alpha (1,4) and creating a new alpha (1,4) on main branch. Also breaks alpha (1,6) to make free glucose. On same enzyme asglycogen phosphorylase

Question 4

Glycogen synthase

Answer 4

Make glycogen by adding 1 glucose from UDP-glucose

Question 5

Phosphorylase kinase

Answer 5

Regulate glycogen phosphorylase activity

Question 6

Protein phosphatase 1

Answer 6

Dephosphorylate protein

Question 7

Protein inhibitor 1

Answer 7

Regulate the phosphatase

Question 8

Branching enzyme

Answer 8

Break alpha(1,4) and make alpha(1,6), transfer 5-8 residues

Question 9

glycogenin

Answer 9

Enzyme that addes first 6 glucose to itself to make glycogen primer with glycogen initiator synthetase activity

Question 10

ras

Answer 10

GTP binding protein

Question 11

PKB (Akt)

Answer 11

Stimulates cell cycle progression and inhibits apoptosis. GF–>PI3–>PKB

Question 12

Bcl-2

Answer 12

pro and anti-apoptotic

Question 13

BAD

Answer 13

pro-apoptotic factor, phosphorylated and inactivated by PKB

Question 14

E2F

Answer 14

TF that is inhibited by Rb (regulated by cyclin) to keep TF from transcription of genes to enter S phase

Question 15

p53

Answer 15

recognizes damaged DNA and acts as TF to stop cell cyclin by inducing CKI

Question 16

BRCA1

Answer 16

Inhibit cell cycle, repair of damaged DNA