DNA flash

Question 1

Dideoxynucleosides

Answer 1

Anti-retroviral, no 2’ or 3’ OH. Terminates chain. Reverse transcription inbitiors (anti-retroviral)

Question 2

Combivir

Answer 2

anti-retroviral drug that uses AZT and 3TC

Question 3

AZT

Answer 3

dideoxynucleoside

Question 4

3TC

Answer 4

dideoxynucleoside

Question 5

DNA template read

Answer 5

3’–>5’

Question 6

New strand is made

Answer 6

5’–>3’

Question 7

DNA Primase

Answer 7

DNA-dependent-RNA-pol. That adds RNA primer

Question 8

DNA pol. 3

Answer 8

Prokaryotic pol. That synthesises new strands, does DNA MMR

Question 9

DNA pol. 1

Answer 9

Both direction exonuclease activity

Question 10

All prokaryotic pol.

Answer 10

Polymerize 5–>3 and exonuclease 3’–>5’ (check previous nucleotide before adding new)

Question 11

Topoisomerase

Answer 11

enzyme that cuts DNA strands to allow rotation to release tension

Question 12

Quinolones

Answer 12

Drug that targets bacterial topoisomerase, leading to cell death

Question 13

Etoposide

Answer 13

Eukaryotic topoisomerase inhibitors that are used for anti-cancer chemotheraputics, treated cells self-destruct because cut cannot be rejoined

Question 14

Telomerase

Answer 14

Reverse transcriptase that adds sequence to 3’ end of chromosome

Question 15

Nucleolus

Answer 15

Specialized location for the rDNA component (rDNA/rRNA synthesis and ribosome assemly), not membrane bound

Question 16

Chromatin

Answer 16

DNA + protein (nucleosome) complex

Question 17

Euchromatin

Answer 17

Stains lightly, less compact, transcriptionally active

Question 18

Heterochromatin

Answer 18

Stains darkly, transcriptionally inactive