Signal Transduction

Question 1

Outline 3 types of cell surface receptors;

Answer 1

1) enzyme-coupled receptors

2) G protein-coupled receptors

3) ion-coupled receptors

Question 2

Outline the general aspects of signal transduction;

Answer 2

• ligand binding

• receptor activation

• recruitment of adaptor proteins to form protein complex’s

• activation of effector proteins

Question 3

What is the largest family of enzyme coupled receptors?

Answer 3

Receptor tyrosine kinases

Question 4

What are kinases?

Answer 4

Enzymes that phosphorylase their target substrates

Question 5

What is epidermal growth factor (EGF receptors)

Answer 5

Stimulate cell survival, growth, proliferation

Question 6

What is grb2?

Answer 6

Growth factor receptor bound protein 2

An adapter protein with SH2 and SH3 domains

Question 7

What is the general mechanism for activation / inactivation?

Answer 7

Signalling proteins generally exist in an on/off state and be shifted from one to the other rapidly