Haematology Flashcards by Aoife Tabi | Brainscape

Q

What is a lymphoblastic and a lymphocyte?

A

Lymphoblast- precursor lymphocyte

Lymphocyte- immune cells

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is haematopoiesis and where does it occur?

A

Formation of the cellular components of the blood

Occurs in the bone marrow

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is arrested differentiation?

A

CD19+CD10 + phenotype “common” ALL

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Where does initiating translocation occur?

A

Within the B cell progenitor rather than the HSC

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Describe cancer in proliferation;

A

Replicative immortality

Sustain proliferation signalling

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Describe ALL in proliferation(

A

Accumulation of lymphoblastic within the bone marrow

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is ALL?

A

Acute lymphoblastic leukaemia

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Describe the first hit in the ‘two hit’ model;

A

Common

Pre-leukaemic clone

Potent cell

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Describe the second step in the ‘two hit’ model;

A

Translocation to ALL

infections

2-15 years

Gene deletion/mutation

How well did you know this?

1

Not at all

2

3

4

5

Perfectly