Cells & Tissues Flashcards
What is the bulk of the heart muscle made up of?
Myocardium
What is the inner surface of the myocardium made up of?
Endothelium
What does the right ventricle pump?
Deoxygenated blood to the lungs
Low pressure 25mmHg
Little resistance to blood flow
Short distance to the lungs
What does the left ventricle pump?
Oxygenated blood to all organs of the body
Higher pressure 120 mmHg
Thick muscular wall
Outline the valves of the heart;
• atrioventricular (bicuspid/mitral/tricuspid)
•semi lunar valves (aortic & pulmonary)
What are atrioventricular valves attached to?
Chordae tendinae
What is the tension of the chordae tendinae regulated by?
Papillary muscles
When ventricles contract what also contracts? And what does this cause?
Popularly muscles also contract
Tightens the chordae tendinae and prevents the valve cusps from everting into the atria
Give some characteristics of cardiac muscle;
Fibres arranged in a latticework
Fibres divide,recombine & spread
Striated appearance
Myofibrils contain actin & myosin
What are intercalated discs?
Cell membranes that separate individual cardiac muscle cells
At each disc cell membranes fuse together
Allow rapid diffusion of ions
What 2 syncytiums is the heart composed of?
Atrial syncytium - two walls of the area
Ventricular syncytium - two walls of the ventricle
What is the average for action potential?
105mV
What is the sequence of excitation?
Involves increase in cytosolic calcium
Contraction of atria & ventricles must be coordinated to prevent AV valves closing during ventricle filling
What are the action potential of the cardiac muscle fibres 3 phases?
- Rapid depolarisation - voltage gates Na+ channels open
- Plateau - voltage gates Ca2+ channels open
- Depolarisation - voltage gated K+ channels open, K+ outflow
Describe the P wave of the ECG;
- SA node fires, atrial depolarisation
- atrial systole