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USLME Kiss my ass and pray > Side Effects pharm > Flashcards

Side Effects pharm Flashcards

1
Q

Digoxin

SFX

A

ECG -dysrythia: paroxysmal tachy, 2:1 heart block

Cholinergic

Abx: normalize K levels

Does not cause hypokalemia, BUT co-presence can lead to decampment of toxicity, heart is overly sensitized to digoxin’s effects

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2
Q

Gynectomastia inducing drugs(5)

A

Some drugs create awkward knockers

Spiranolactone
Digitalis
Cimetidine
Alcohol
Ketokonazole
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3
Q

Cimetidine (3)

SFX

A

Inhibits cytochrome p450
antiadronogenic effects
cross BBB

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4
Q

Antibiotics to Avoid in pregnancy

8

A

SAFe Children Take Really Good Care

Sufonamides - kernicterus
Aminoglycosides  -otoxicity
Flouroquinolones - Cartilage damage
Clarithromycin - embryotoxic
Tetracyclines - disolored teeth, inhib bone growth
Ribavirin -  teratogenic
Griseofulvin - tertogenic
Chloramphenicol - gray baby
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5
Q

Celecoxib problem that is not w/ other NSAIDs

A

sulfa allergies

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6
Q

trazadone

SFX

A

trazaBONE

priapism, postural hypersensitivity, sedation, nausea

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7
Q

Buproprion

SFX

A

Siezure in buliemic patients

sitmulant effects

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8
Q

Mirtazapine

SFX

A

increases appetite and dry mouth

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9
Q

Category X drugs (6)

SFX

A 
methotrexate- folate deficiency
isotreinism -spontaneous abortion, HoxD13
warfarin - spontanteous abortion
statin - CNS/ limbs
Thalidomide - limbs
DES - clear cell vaginal adenocarcinoma
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10
Q

Heart and limbs develop around

A

week 4

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11
Q

Genetalia develop around week

A

week 10

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12
Q

Fetal movement begins

A

week 8

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13
Q

Abx to stop if pregnant

A

tetracycline - teeth
aminoglycosides - ototoxicity
floroquinoones - bones

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14
Q

seizure disorder and pregnant - stop what 3 drugs

A

phenytoin
valproic acid
arbamesepine

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15
Q

Hypertension medication to stop in pregnancy

A

ACE inhibitors - renal damage

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16
Q

Drugs that induce P450? (7)

A

Coronas, Guiness and PBRS lead to CHRONIC ALCHOLSIM

Carbamazapine
Griseofulvin
Phenytoin
Barbiturates
Rifampin
St Johns Wart
Chronic alcoholism
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17
Q

Drugs linked to steven Johnson Syndrome (8)

A 
Anti epileptics
- ethosuxamide
-lamotriginine
-carbamazepine
-phenytoin
-phenobarbitol
Abx:
-sulfonamides
-penicillins
Allopurinol
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18
Q

Drugs linked to Agranulocytosis(5)

A

Carbamazepine - siezure
clozapine - antipsych
colchicine - gout
propothiouracil and methimazole - antithyroid

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19
Q

Blood dysrasia seizure medication (2)

A

carbamazipine

ethosuximide

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20
Q

Cutaneous Flushing drugs (4)

A

VANC

Vancomycin
Adenosine
Niacin
Ca channel blockers - Amlodipine, nefidipine

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21
Q

Coronary Vasospasm drugs (5)

A 
Cocaine
Sumatriptans
ergot alkaloids 
amphetamine
methamphetamine
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22
Q

Dilated cardiomyopathy SFx (2)

A

Doxorubicin - adriamycin

daunorubicin

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23
Q

Torsades de Pointes SFx Drugs(6)

Rx w?

A

Macrolides
haloperidol
chloroquine
protease inhibitors
Class III - K channel blockers (Amniodarone)
Class IA - Na channel blockers (quinidine)

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24
Q

AgranuloCytosis SFx Drugs (6)

A

Clozapine
Carbamazapine
Colchacine

Propylthiouracil
methimazole

dapsone

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25
Q

Aplastic Anemia (5)

A

Chloramphenicol
benzene
NSAIDs

propylthiouracil
methimazole

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26
Q

Grey baby syndrome

Pathogenesis

A

Chloramphenicol

low UDP glucoronyl transferase low in babies

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27
Q

anemia (hemolysis) in G6PD SFx

A 
isoniazid
Sulfonamides
Primaquine
HIGH ASA
Ibuprofen
Nitrofuranitoin
Dapsone
Fava Beans
Naphalene
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28
Q

Why are we worried about OCPs in smokers over 35?

A

Risk of thrombotic complications

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29
Q

Thrombocytopenia Drug SFx (2)

A

Heparin

Cimetidine

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30
Q

Pulmonary Fibrosis Drug SFx (3)

A

Amiodarone - Check LFTs, TFTs, PFTs

Bleomycin
Busulfan

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31
Q

Cough due to a medication

due to

A

Ace inhibitors

Bradykinin

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32
Q

Hepatic Necrosis drug SFx(4)

A

Halothane
Amantia phalloides - mushroom
Valproic acid
Acetaminophen

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33
Q

Hepatitis Drug SFx (1)

A

Isoniazid

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34
Q

Pseudomembranous colitis (3)

A

clindamycin
ampicillin
amoxicillin

35
Q

Hot flashes SFx(2)

A

Tomoxifen
clomiphene
(SERMs - > high LH and FSH levels)

36
Q

Adrenocortical insufficiency

A

corticosteriod withdrawal

37
Q

Hypothyroidism drug SFx (3)

A

Lithium
amiodarone
sulfonamides

38
Q

Gout exacerbation drug SFx (5)

A 
Furosimide
thizazide
niacin
cyclosporine
pryazinamide
39
Q

Gingival hyperplasia Drug SFx (2)

A

*Phenytoin

verapamil

40
Q

Osteoporosis Drug SFx (2)

A

corticosteroids

heparin

41
Q

Photosensitivity Drug SFx (2)

A

SATs for PHOTO

Sulfonamides
Amiodarone
Tetracycline

42
Q

Stevens Johnson Rash Drug (4)

A 
Penicillin
sulfa drugs
allopurinol
Anti siezure
- ethosuximide
-carbamazepine
-lamotrigine
-phenytoin
-phenobarbital
43
Q

Drug induced SLE (5)

A

SHIPP

Sulfonamides
hydralazine
INH 
Procainamide
Phenytoin
44
Q

Tendonitis and rip in tendon drug SFx

A

fluoroquinolones

45
Q

Diabetes insipidus Drug SFx (2)

A

Lithium

demeclocycline

46
Q

Fanconi’s syndrome Drug SFx (2)

-What is it?

A

expired tetracycline, heavy metal exposure

proximal tube defect leading to spillage of required items

can also be caused by wilsons disease

47
Q

Interstitial nephritis Drug SFx (3)

A

Abx (methicillin)
NSAIDs
furosemide

48
Q

Cinchonism

What is it?

What drugs are associated? (2)

A

Dizziness w/ HA, vision changes and tinnitus

Quinidine (class IA antiarrythmic) and quinine

49
Q

Parkinson like symptoms Drug RXn (3)

A

Lowering Dopamine
antipsychotics
reserpine (packages)
metoclopramide (given for gastroparesis maybe?)

50
Q

Seizure inducing drugs(5)

A 
isoniazid
Buproprion
Imipenem/cilastatin
Tramadol
Metoclopramide
51
Q

Tardive Dyskinesia

A

antipsychotic

52
Q

Antimuscarinic SFx (4)

A

Atropine
TCAs
H1 blockers
Neuroleptics - thiordazine, chlorpromazine

53
Q

Nephrotoxicity w/ ototoxicity(4)

A

Aminoglycosides
vancomycin
loop diuretics
cisplatin

54
Q

nephrotoxicity w/ neurotoxicity (3)

A

aminoglycosides*
cisplatin*
polymixin

ototoxic as well

55
Q

Methanol in the body is converted to what toxic metabolite

A

formaldehyde

56
Q

Ethylene glycol in the body is converted to what tosco metabolite

A

oxelic acid

57
Q

Acetaminophen toxicity?

works by?

A

n acetycysteine

replenishing glutathione that helps w/ NPAQI metabolites that damage hepatocytes

58
Q

presentation of N/V dizzy and tinnitus - overdose of?

Rx?

A

ASA

NaHCO3

59
Q

Presentation of bad teeth and anxiety and confusion, excitability?

Rx

A

Methamphetamine

NH4Cl

60
Q 
Antimuscarinic overdose (dry as a bone, blind as a bat )
Rx?
A

physostigmine

61
Q

overdose of verapamil and beta blocker -> bradycardia

Rx (3)

A

Glucagon -> increases cAMP in myocardium
atropine
Ca

62
Q

Digitalis overdose see?

Rx(2)

A

arrythmia and electrolyte imbalance

Anti dig Fab
normalize K

63
Q

Kid eats too many vitamins worry of what?

Symptoms of Ab pain, hematuriosis, melana, lethargy

Rx?

A

Iron overload

DeFeroxamine,

DeFerasirox

64
Q

Kid with developmental delays, basophilic stippling, nonspecific GI worry of?

Rx?(3)

A

Lead poisoning

Dimercaperol, EDTA, Succimer

65
Q

Mercury, arsenic or gold poisoning Rx?(2)

A

Dimercaperol

Succimer

66
Q

Copper, Arsenic, gold Rx

A

Penicillamine

67
Q

Patient comes from a house fire and maybe has cyanide poisoning

Rx ?(3)

A

nitrites
thiosulfate
hydroxocobalamin

68
Q

Methemoglobin Rx (2)

A

Methylene Blue

Vitamin C

69
Q

Patient presents w/ very red lips and uses a kerosine lamp to heat his car worry of?

Rx?

A

Carbon monoxide poisoning

100% O2

70
Q

Methanol or ethylene glycol poisoning Rx

A

Fomeprizol

Ethanol also

71
Q

Benzodiazapine overdose Rx?

Worry of

A

Flumazenil

Seizures

72
Q

OPiods in a mother prior to labor and she delivers early, give what to the baby?

73
Q

TCA overdose?

A

NaHCO3 - alkalize the urine

74
Q

Heparin overdose?

75
Q

Warfarin overdose initially and over time?

A

FFP if quick

vit K 3-5 days

76
Q

TPA, Streptokinase and urokinase overdose Rx

A

aminocaproic acid

77
Q

Thophylline overdose see?

Rx?

A

Tachy, arrhythmic - narrow TI

beta blocker

78
Q

Drugs that SHOULD NOT be given to sulfa allergy patients(8)

A 
Celecoxib
sulfonamides - TMP-SMX
acetazolamide - carbonic anhydrase inhib
Loop diuretics - furosemide
Thiazide diuretics
Probenacid - gout excreter 
Sulfonylureas - DM II
sulfasalazine - Ulcerative colitis
79
Q

Sulfa Drugs Frequently Cause Terrible Acute Symptoms

A 
Sulfasalazine /(TMP-SMX)
probenaciD
Furosemide (loops)
Celecoxib
Thiazide 
Acetazolamide
Sulfonureas
80
Q

Side effects of Sulfonamides(6)

A

hypersensitivity*

hemolysis w/ G6PD def

nephrotoxixity - tubointerstial nephritis

photosensitivity

kernicterus in infants (N overload peri-birth)

displacement from alumin (warfarin)

81
Q

TMP-SMX indications(4)

A 
UTI
Shigella
Salmonella
Pneumocisitis jirovecii
-prophylactic <200 CD4
82
Q

TMP-SMX toxicity(3)

-TMP concerns

A

megaloblastic anemia
leukopenia
grancytopenia

Rx- folic acid rescue - leucovorin

83
Q

Floroquinalone concerns (3)

A

tendonitis
-tendon rupture
Contraindicated in pregnancy and kids due to hardness on articular cartilage

USLME Kiss my ass and pray (33 decks)

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