IHO Cancer Flashcards
RET
neural growth factor receptor, MEN2A andMEN2b
KIT
Stem cell growth factor receptor, GI stromal tumor
ERBB/HER2
Epidermal growth factor receptor; amplification, breast carcinoma
PDGFB
Platelet derived growth factor; over expression; Astrocytoma
RAS (3 cancers)
GTP binding protein - sig transduction, Carcinoma, melanoma, lymphoma
ABL (2 types)
Tyrosine Kinase - sig transduction; 9:22 w/ BCR, CML and some ALL
c-myc
Transcription factor; t(8;14) of IgH; Bukitt lymphoma -
t(9:22)
CML and some AML
Tyrosine kinase
t(8:14)
Burkett Lymphoma - starry sky
14-IgHeavy chain
8- c-myc nuclear regulator
n-myc
transcription factor, Amplification, Neuroblastoma
l-myc
Transcription factor, Amplification, Lung carcinoma, small cell
t(11;14)
Mantle cell carcinoma
14-Ig
11-cycD
CDK4
Cyclin dependent kinase; cell cycle reg; amplification, Melanoma
Top 3 cancer by death -
Lung, breast/prostate, colorectal
Top 3 cancer
Breast/prostate, lung, colorectal
Afalatoxins carcinogen
hepatocellular carcinoma, aspergillus
Alkylating agents carcinogen
leukemia/lymphoma
arsenic carcinogen
Squamous cell skin, lung, angiosarcoma
asbestos carcinogen
lung carcinoma, mesothelioma
Nitrosamines carcinogen
Stomach cancer, smoked foods
naphthyalamine- carcinogen
urothelial carcinoma bladder
vinyl chloride carcinogen
angiosarcoma, PVC exposure
nickel, chromium, beryllium ,silica carcinogen
lung carcinoma
EBV carcinogen(3)
Nasopharynx, Burkitt lymphoma, CNS lymphoma
HHV8 carcinogen
Kaposi sarcoma
HBV/HCV carcinogen
hepatocellular carcinoma
HTLV1 carcinogen
adult t cell leukemia/lymphoma
HPV carcinogen(2 cancers) (3 high risk groups)
squamous cell carcinoma and adenocarciona of cervix - 16, 18, 31
Radiation(ionizing) carcinogen (3)
AML, CML, Papillary carcinoma of thyroid (unique)
Nonionizing radiation carcinogen(UVB) - (3)
basal cell, squamous cell, melanoma
p53
regulates G1-S phase, upregulates BAX to disrupt Bcl2 and induce apoptosis
Bcl2
Maintains mitochondria membrane, cytochrome C escapes induce apoptosis
Rb
holds E2 TF, necessary for S phase, phosphorylated to bbs released by Cyclin D; mutations retinoblastoma and osteosarcoma
E2f
transcription factor
t(14:18)
follicular lymphoma, Bcl2 is over expressed;
14-Ig
18- BCL2
Tumor marker - bone METS, liver and Pagets disease
alkaline phosphatase
Tumor marker beta hCG seen in (2)
Hydratiform moles
Choriocarcinomas
Ovarian cancer tumor marker
CA-125
Melanoma, neural tumors and schanomas have this tumor marker
S-100
Hairy cell Leukemia diagnosis stain and smear
Stains TRAP - tartate- resistant acid phosphatase
Cells have filmentous hair like projections
Hairy cell Leukemia symptoms
Pancytopenia - unique
Splenomegaly
cells w/ “hair”
affects middle age men
