IHO Cancer

Question 1

RET

Answer 1

neural growth factor receptor, MEN2A andMEN2b

Question 2

KIT

Answer 2

Stem cell growth factor receptor, GI stromal tumor

Question 3

ERBB/HER2

Answer 3

Epidermal growth factor receptor; amplification, breast carcinoma

Question 4

PDGFB

Answer 4

Platelet derived growth factor; over expression; Astrocytoma

Question 5

RAS (3 cancers)

Answer 5

GTP binding protein - sig transduction, Carcinoma, melanoma, lymphoma

Question 6

ABL (2 types)

Answer 6

Tyrosine Kinase - sig transduction; 9:22 w/ BCR, CML and some ALL

Question 7

c-myc

Answer 7

Transcription factor; t(8;14) of IgH; Bukitt lymphoma -

Question 8

t(9:22)

Answer 8

CML and some AML

Tyrosine kinase

Question 9

t(8:14)

Answer 9

Burkett Lymphoma - starry sky
14-IgHeavy chain
8- c-myc nuclear regulator

Question 10

n-myc

Answer 10

transcription factor, Amplification, Neuroblastoma

Question 11

l-myc

Answer 11

Transcription factor, Amplification, Lung carcinoma, small cell

Question 12

t(11;14)

Answer 12

Mantle cell carcinoma
14-Ig
11-cycD

Question 13

CDK4

Answer 13

Cyclin dependent kinase; cell cycle reg; amplification, Melanoma

Question 14

Top 3 cancer by death -

Answer 14

Lung, breast/prostate, colorectal

Question 15

Top 3 cancer

Answer 15

Breast/prostate, lung, colorectal

Question 16

Afalatoxins carcinogen

Answer 16

hepatocellular carcinoma, aspergillus

Question 17

Alkylating agents carcinogen

Answer 17

leukemia/lymphoma

Question 18

arsenic carcinogen

Answer 18

Squamous cell skin, lung, angiosarcoma

Question 19

asbestos carcinogen

Answer 19

lung carcinoma, mesothelioma

Question 20

Nitrosamines carcinogen

Answer 20

Stomach cancer, smoked foods

Question 21

naphthyalamine- carcinogen

Answer 21

urothelial carcinoma bladder

Question 22

vinyl chloride carcinogen

Answer 22

angiosarcoma, PVC exposure

Question 23

nickel, chromium, beryllium ,silica carcinogen

Answer 23

lung carcinoma

Question 24

EBV carcinogen(3)

Answer 24

Nasopharynx, Burkitt lymphoma, CNS lymphoma

Question 25

HHV8 carcinogen

Answer 25

Kaposi sarcoma

Question 26

HBV/HCV carcinogen

Answer 26

hepatocellular carcinoma

Question 27

HTLV1 carcinogen

Answer 27

adult t cell leukemia/lymphoma

Question 28

HPV carcinogen(2 cancers) (3 high risk groups)

Answer 28

squamous cell carcinoma and adenocarciona of cervix - 16, 18, 31

Question 29

Radiation(ionizing) carcinogen (3)

Answer 29

AML, CML, Papillary carcinoma of thyroid (unique)

Question 30

Nonionizing radiation carcinogen(UVB) - (3)

Answer 30

basal cell, squamous cell, melanoma

Question 31

p53

Answer 31

regulates G1-S phase, upregulates BAX to disrupt Bcl2 and induce apoptosis

Question 32

Bcl2

Answer 32

Maintains mitochondria membrane, cytochrome C escapes induce apoptosis

Question 33

Rb

Answer 33

holds E2 TF, necessary for S phase, phosphorylated to bbs released by Cyclin D; mutations retinoblastoma and osteosarcoma

Question 34

E2f

Answer 34

transcription factor

Question 35

t(14:18)

Answer 35

follicular lymphoma, Bcl2 is over expressed;
14-Ig
18- BCL2

Question 36

Tumor marker - bone METS, liver and Pagets disease

Answer 36

alkaline phosphatase

Question 37

Tumor marker beta hCG seen in (2)

Answer 37

Hydratiform moles

Choriocarcinomas

Question 38

Ovarian cancer tumor marker

Answer 38

CA-125

Question 39

Melanoma, neural tumors and schanomas have this tumor marker

Answer 39

S-100

Question 40

Hairy cell Leukemia diagnosis stain and smear

Answer 40

Stains TRAP - tartate- resistant acid phosphatase

Cells have filmentous hair like projections

Question 41

Hairy cell Leukemia symptoms

Answer 41

Pancytopenia - unique
Splenomegaly
cells w/ “hair”

affects middle age men