IHO Disease Flashcards

1
Q

HLA DR3/Dr4

A

increased risk of DM1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Heinz body -
what is it ?
what is it seen in (2)?

A

oxidized hemogobin w/in RBC

seen in G6P dehydrogenase deficiency and thallasemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Red urine w/out RBC

A

hemoglobinuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

nuclear elements in RBC

A

Holly Jolly bodies, seen post splenectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Seronegative Spondyloarthropathies - Arthritis w/out rheumatoid factor - no anti Ig Ab (4)

A

PAIR - HLA B27 associated

Psoriatic Arthritis - joint pain w/psoriasis

Ankylosing spondylitis - bamboo spine

Inflammatory Bowl Disease - Crohns and UC

Reactive Arthritis(Reiter Syndrome) - Conjunctivitis, Urethritis, Arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Primary Amyloidosis - seen and associated w/

A

AL systemic deposition
-Ig light chain derived

Plasma cell dyscrasias - multiple myelinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Secondary Amyloidosis - seen and associated w/

A

SAA -> AA systemic deposition
-acute phase reactant increased in chronic inflam states and Familal Mediterranium Fever

Nephrotic syndrome - kidney most common
Restrictive cardiomyopathy
Tounge enlargement, malabsorbtion, arrhythmia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Senile Cardiac amyloidosis

A

serum non-mutated transthyretin in heart, usually asymptomatic
>80 yrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Familal amyloid cardiomyopathy

A

serum mutated transthyretin deposits -> restrictive cardiomyopathy

African americans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Alzheimer disease amyloid type and who has higher risk?

A

A beta
depostis in brain forming plaques

Beta APP on chromosome 21 making down at increased risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Dialysis associated

A

beta2 microglobulin

not filtered well and builds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Medullary Carcinoma

A

calcitonin deposits within tumor

tumor cell in amyloid background

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

hemolytic anemia, pancytopenia and venous thrombosis think of?

More often seen?

A

Paroxysmal nocturnal hemoglobinuria

Seen in the morning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Paroxysmal nocturnal hemoglobinuria due to ?

A

increased complement mediated RBC lysis

-missing decay accelerating factors (CD55/59)
or
- decreased synth of GPI anchor (PIG-A)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly