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USLME Kiss my ass and pray > Endo/Repro Drugs > Flashcards

Endo/Repro Drugs Flashcards

1
Q

terbutaline

A

b2 agonist
- activate adenylel cyclase -> raise cAMP-> phosphorylatase-> MLCK blocking

tocolytic
-suppress uterine smooth muscle

IV or PO

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2
Q

Ritodrine

A

b2 agonist
-activate adenylel cyclase -> raise cAMP -> phosphorylatase-> MLCK blocking

tocolytic
- suppress uterine smooth muscle

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3
Q

Magnesium Sulfate

A

tocolytic
IV
Competes w/ Ca and relaxes Smooth Muscle

Prevent seizures

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4
Q

Atosibane

A

Ocytocin receptor ANTAGONIST

delays labor

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5
Q

Pitocin

A

Oxytocin synthetic

oxytocic

Gq

Uterine contractions, milk let down, ADH and vasoactive and high concentrations

NO oral

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6
Q

Dinoprostone

A

prostaglandin (E)- hyperalgesia
oxytocic

softening of cervix
uterine contrations

abortifacent - vaginal suppository
- hydratiform mole

Gs

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7
Q

Carboprost

A

prostaglandin (F)
oxytocic

Uterine contractions

abortifacent
- IM

Gq

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8
Q

misoprostol

A

prostaglandin(E)
oxytocic

Softening of the uterus
uterine contractions

Vaginal or Oral
used / progesterone antagonist - mifepristone

Gs

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9
Q

Ergonovine

A

ergot
oxytocic

contraction of the uterus(NOT USED)
and postpartum bleeding

alpha adrenergic, dopaminergic and 5HT2 receptors

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10
Q

Ergotamine

A

ergot

Contraction of blood vessels - more for migraine HA

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11
Q

Indomethacin

A

reduces oxytocin induced uterine contractions

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12
Q

oxytocin receptor

A

Gq protein -> phospholiase C -> increased Ca

Need Mg and Cholesterol allosteric

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13
Q

Goserelin

A

GnRH analogue
-flare of symptoms before down regulation of receptors

prostate and ER + cancer (pre menopause)

low testosterone problems…

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14
Q

Leuprolide

A

GnRH Analogue
-flare of symptoms (given w/ flutamide) before down regulation of receptors

prostate and ER + cancer (pre menopause)

Low testosterone problems…

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15
Q

Degarelix

A

GnRH competitive antagonist

NO surge, much faster
in prostate and assister repro use

Shorter duration of action -> cost and compliance

Class promotes histamine release -> hypotension and allergic rxns, rash

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16
Q

Dutasteride

A

5 alpha reductase inhibitor

Testosterone -> DHT blocked

Used for BPH and baldness, prostate CA prevention

teratogenic

17
Q

finasteride

A

5 alpha reductase inhibitor

Testosterone -> DHT blocked

Used for BPH and baldness, prostate CA prevention

teratogenic

18
Q

Aminoglutethimide

A

Aromatase inhibitor- nonsteriodal/reversible

cholesterol -> pregnenolone (higher up)

Can mimic Adrenal Insufficiency
-myelosuppression

19
Q

Anastrozole

A

aromatase inhibitor - nonsteriodal/reversible

testosterone ->estradiol in ovary (pre meno)

androstenedione -> estrone in adipose (POSTmeno)

polyarthralgia
bone density
Better lipid?

20
Q

letrozole

A

aromatase inhibitor -nonsteriodal/reversible

testosterone ->estradiol in ovary (pre meno)

androstenedione -> estrone in adipose (POSTmeno)

polyarthralgia
bone density
better lipid?

21
Q

Bicultamide

A

Anti androgen receptor

ADT therapy - Prostate
- given to fight flare w/ GnRH agonists( still have high testosterone but no effect)

Inhibit ligand binding and translocation

Not used long term or alone

22
Q

Flutamide

A

Anti androgen receptor

ADT therapy - prostate
-given to fight GnRH agonist flare (still have high testosterone but no effect)

Inhibit ligand biding and translocation

not used long term or alone

older more side effects - gynectomastia, liver function, Diarrha, N/V, low testosterone effects

23
Q

Nilutamide

A

Anti androgen receptor

ADT therapy - prostate
-given to fight GnRH flare (still have high testosterone but no effect)

Inhibit ligand binding and translocation

not used long term or alone

24
Q

Raloxifene

A

anti estrogen(SERM)

oral, peaks hrs
NO benefit after 5 yrs

Good for all 3 - breast antagonist, uterus antagonist, bone agonist

25
Q

tamoxifen

A

anti estrogen(SERM)

oral, peaks hrs
no benefit after 5yrs
GO TO drug for ER +

prevention of invasive carcinoma

Good: Breast antagonist, bone agonist

Given w/ GnRH analogue - due to inhib negative feedback (higher estradiol w/out)

Bad: Uterus agonist - endometrial CA

Also stroke risk

26
Q

toremifene

A

Anti estrogen(SERM)

oral, peaks hrs
no benefit after 5 yrs

Good: Breast antagonist

Bad: Uterus agonist

27
Q

Fulvestrant

A

anti Estrogen (SERD)

IM, peaks 7 days

Cyp3A4 concern

Competitive antagonist in EVERY tissue - hard on bone…

back pain, HA, phayngitis, GI

28
Q

FAC regiment (1st)

A

5 fluoruacil
-anti metabolit

Adriamycin -doxyrubicin

  • anthracycaline
  • cardiotoxicity and local necrosis

cyclophasphamide

  • alkylating agent
  • hemorrhagic cyst worries
29
Q

CMF regiment (2nd)

A

Cyclophosphamide

Methotrexate
- switch out of doxyrubacin when toxicity met

5 fluoruracil
-antimetabolite

30
Q

Traztuzumab

A

Ab against HER2 surface marker

31
Q

Paclitaxel

A

binds to tubulin to enhance and stabilize spindle formation

USLME Kiss my ass and pray (33 decks)

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