Side Effects Flashcards
Why Na/I symporters are not used ?
Toxic and less preferred
Side effect of Propylthiouracil
Hepatoxicity
Side effect of Carbimazole which is prog drug of methimazole
Teratogenic
Cholestatic Jaundice
Which teratogenic disease are caused by Carbimazole
Cutis Aplasia (scalp skin)
Choanal or esophageal atresia
What are sideeffects of thioamide drugs
Skin: Maculopapular Rash
Blood: Agranulocytosis
Joints: Arthralgia
Side effects of Iodides
Headache
Dysgeusia
Rash
Lymphadenopathy
What worsens when I 131 is given in Recurrent Graves and what should be given to prevent
Ocular Symptoms
Steroids
Radioactive iodines side effects
Hypothyroidism
Radiation Thyroditis
Secondary Cancers
What are side effects of alpha glucosidase inhibitors
Flatulence
Osmotic Diarrhea
Abdominal cramping
(Due to undigested carbohydrates degradation by bacteria in intestine)
GLP 1 analogues
Nausea
Vomiting
Weight loss
(Delay gastric emptying)
Gliptins
And specific
Saxa and Alo
Vilda
Itis
(increased risk of infections as its structure similar to CD 26 leads to decreasee lymphocytes activity)
Hypersensitivity reaction: Steven Johnson Syndrome
Angioedema
Pancreatitis
Nasopharyngitis
Pain
Severe disbabling joint pain
DM
Type 1
Diabetic Ketoacidosis
Saxa and Alo:CHF
Vilda: Hepatitis
Pramlinitide
Nausea
Vomiting
Weight loss
Insulin
Why? And if can then how to correct?
(5)
Hypoglycemia (<70 mg/dl)
Signs and symptoms (<55 mg/dl)
Correct:
Unconsious: IV dextrose
Consious: candy, glucose tablets or fruit juice)
Otherwise Glucagon IM or IN
Hypokalemia
(Moves both K and Glu into cells)
Edema and Allergy
Lipodystrophy
Lipohypertrophy
(Keep rotating or changing site of injection by 1 inch)
Somogyi effect
(Rebound hyperglycemia due to hypoglycemic episodes lead to increase cortisol and adrenaline)
Correct: dose of insulin at bedtime or change time of dosing
Dawn phenomenon
(Inadequate insulin in morning leading to hyperglycemia in early hours)
Correct: Increase bed time insulin for normoglycemia thoroughout night and early hours of morning
SulfonylUreas and Glinides
Hypoglycemia>
Weight gain>
Hyperinsulinemia only 1
1st generation specific
Tolbutamide: Hepatotoxic
Chlorpropamide: SIADH followed hy dilutional hyponatremia
Cholestatic jaundice
Disulfiram like reaction
Guanides basically metformin
Correct:
GIT: Nand V, diarrhea
(Titrating the dose slowly and with meals)
Calcium dependent Vitamin B12 absorption decreased
Especially in anemia or peripheral neuropathy
(Supplements)
Lactic Acidosis due to interefernce in aerobic glycolysis in mitochondria