Endocrine System Flashcards
Na/I symporter Inhibitors
Thiocyanate
Fluoroborate
Perchlorate
Drugs under Thioamide which block Thyroxine Peroxidase
Propylthiouracil
Methimazole
What is the drug of choice for hyperthyroidism/Grave’s disease?
Methimazole
What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?
Propylthiouracil
What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?
1st trimester
Propylrhiouracil
What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?
2nd and 3rd trimester
Methimazole
What is drug of choice for hyperthyroidism/Grave’s disease in LACTATION?
Propylthiouracil
What is drug of choice for Thyrotoxicosis/Thyroid Storm?
Propylthiouracil
Remeber to add in MOA
What is drug of choice for SEVERE Thyrotoxicosis/Thyroid Storm?
Propanolol
(Avoid Arrythmia)
Drugs which come under Iodides
Lugol’s iodide:5%
Potassium iodide:10%
Iodide can be used for?
Thyroid Surgery
(Make it firm and small)
Nuclear Accidents
(As it blocks uptake of radioactive substance)
Thyroid Storm
(Given after methimazole)
Drugs under 5’-deiodinases
(Blocks peripheral conversion of T4 to T3)
Amiadorone
Beta-Blockers
Steroids
Propylthiouracil
Drugs under radioactive iodine
I 123
I 131
Radioactive Iodine
I 131
Hyperthyroidism in cardiac and elderly
Toxic Nodular Goitre
Thyroid Cancer
Recurrent Grave’s
What are the features of Levothyroxine
Less potent and Longer acting
What is the drug of choice for replacement in hypothyroidism
Levothyroxine
Features of T3/Leothyronine
More potent and shorter acting
Uses of T4/Levothyroxine
IV Route:Myxedema Coma
Thyroid Cancers
(Reduce TSH)
Uses of T3/Liothyronine
Myxedema Coma
I 131 Therapy
Drug under Alpha glucosidase inhibitors
Acarbose
Voglibose
Miglitol
Use of alpha glucosidase inhibitors
Type 2 DM
Which is drug of choice for obesity
Liraglutide
Drugs which are DPP4 inhibitors
SSavli (Gliptins)
Sita
Saxa
Alo
Vilda
Lina
Dape
Amylin analogue name
Pramlintide
Classification of insulin
Shortest and fastest acting: Afrezza Insulin
Short acting
Fast: Glusine, Lispro, Aspart
Slow: Regular Insulin
Intermediate acting:
Isophane Insulin/Neutral protamine hagedorn (NPH)
Lente Insulin
Long acting:
Glargine
Detemir
Degludec
What is drug of choice for diabetic ketoacidosis
IV regular insulin
OHA which increase insulin release
Sulfonylureas
Glinides
Names of drug under sulfonylurease
2nd generation
Glibenclamide
Glyburide
Glipizide
Glimepiride
Drugs under glinides
Megaglitinides
Repaglinides
Phenylalanine analogue
Nateglinides
Sulfonylureas 1st generation drugs
Acetohexamide
Tolbutamide
Chlorpropamide
Features of 2nd generation sulfonylureas
(4)
Glyburide or Glibenclamide :
It has an active metabolite. The drug gets concentrated in the ẞ islet cells and thus is longer acting than its half-life (T). OD dosing is sufficient.
Glimepiride: Sulfonylurea with least dose requirement to induce
hypoglycemia.
Gliclazide:
It has an additional antiaggregant effect.
Glipizide:
short acting. Lesser risk of hypoglycemia, hence preferred in elderly patients.
Which guanide was banned ?
Phenformin due to severe lactic acidosis
Drug of choice for treatment of DM 2
Metformin
Drug of choice for ptophylaxis in pre-diabetics
Metformin
Which drug is banned in USA and comes with black box warning in India
Piloglitazone
SGLT 2 inhibitors
Glifozin
Cana
Dapa
Empa
Ertu
Group of Drug of choice for Secretory Diarrhea
Somatostatin Analogues
Drug group of choice in Tumors like
Glucagonoma
• VIPoma
• GRFoma.
• Somatostatinoma
Somatostatin Analoguee
Drug of choice in variceal bleeding
Terlipressin
Features of Somatostatin
Location
LOCATION: Intestine, Stomach, Pancreas, Hypothalamus
2.INHIBIT:
Gastrin
Insulin
Glucagon
Growth Hormone
Gonadotropins names
1.hMG
2. FSH
3.LH
MENOTROPIN
Urofollitropin
Folliotropin a &B.
HCG
Choriogonadotropin alpha
Which androgen anatagonist aling with goserelin depot is used for prostate carcinoma
Bicalutamide
GNRH agonists and analogues
Gonadorelin
Leuprolide
Goserelin
Nafarelin
Buserelin
Triptorelin
GNRH antagonists
Cetorelix
Ganirelix
Elagolix
Abarelix
Which should be always given along estrogen to reduce risk of endometrial carcinoma
Progestogen
In which condition can estrogen be used alone
Hysterectomy
HT have substantially less estrogen than contraceptipn
True
Which drug is a 19-nonsteroid used for HRT and its metabolite have estrogenic, progestrogenic and androgenic properties
Tibolone
Most potent bisphpsphanates
Zoledronate
Which drug is drug of choice for osteoporosis
Bisphosphonates
Which drug is drug of choice for hypercalcemia of malignancy
Bisphosphonates
Which drug is drug of choice for pagets’ disease
Bisphosphonates
