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Pharmacology > Endocrine System > Flashcards

Endocrine System Flashcards

1
Q

Na/I symporter Inhibitors

A

Thiocyanate
Fluoroborate
Perchlorate

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2
Q

Drugs under Thioamide which block Thyroxine Peroxidase

A

Propylthiouracil
Methimazole

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3
Q

What is the drug of choice for hyperthyroidism/Grave’s disease?

A

Methimazole

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4
Q

What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?

A

Propylthiouracil

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5
Q

What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?
1st trimester

A

Propylrhiouracil

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6
Q

What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?
2nd and 3rd trimester

A

Methimazole

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7
Q

What is drug of choice for hyperthyroidism/Grave’s disease in LACTATION?

A

Propylthiouracil

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8
Q

What is drug of choice for Thyrotoxicosis/Thyroid Storm?

A

Propylthiouracil
Remeber to add in MOA

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9
Q

What is drug of choice for SEVERE Thyrotoxicosis/Thyroid Storm?

A

Propanolol
(Avoid Arrythmia)

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10
Q

Drugs which come under Iodides

A

Lugol’s iodide:5%
Potassium iodide:10%

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11
Q

Iodide can be used for?

A

Thyroid Surgery
(Make it firm and small)
Nuclear Accidents
(As it blocks uptake of radioactive substance)
Thyroid Storm
(Given after methimazole)

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12
Q

Drugs under 5’-deiodinases
(Blocks peripheral conversion of T4 to T3)

A

Amiadorone
Beta-Blockers
Steroids
Propylthiouracil

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13
Q

Drugs under radioactive iodine

A

I 123
I 131

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14
Q

Radioactive Iodine
I 131

A

Hyperthyroidism in cardiac and elderly
Toxic Nodular Goitre
Thyroid Cancer
Recurrent Grave’s

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15
Q

What are the features of Levothyroxine

A

Less potent and Longer acting

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16
Q

What is the drug of choice for replacement in hypothyroidism

A

Levothyroxine

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17
Q

Features of T3/Leothyronine

A

More potent and shorter acting

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18
Q

Uses of T4/Levothyroxine

A

IV Route:Myxedema Coma
Thyroid Cancers
(Reduce TSH)

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19
Q

Uses of T3/Liothyronine

A

Myxedema Coma
I 131 Therapy

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20
Q

Drug under Alpha glucosidase inhibitors

A

Acarbose
Voglibose
Miglitol

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21
Q

Use of alpha glucosidase inhibitors

A

Type 2 DM

22
Q

Which is drug of choice for obesity

A

Liraglutide

23
Q

Drugs which are DPP4 inhibitors

A

SSavli (Gliptins)
Sita
Saxa
Alo
Vilda
Lina
Dape

24
Q

Amylin analogue name

A

Pramlintide

25
Q

Classification of insulin

A

Shortest and fastest acting: Afrezza Insulin

Short acting

Fast: Glusine, Lispro, Aspart
Slow: Regular Insulin

Intermediate acting:
Isophane Insulin/Neutral protamine hagedorn (NPH)
Lente Insulin

Long acting:
Glargine
Detemir
Degludec

26
Q

What is drug of choice for diabetic ketoacidosis

A

IV regular insulin

27
Q

OHA which increase insulin release

A

Sulfonylureas
Glinides

28
Q

Names of drug under sulfonylurease
2nd generation

A

Glibenclamide
Glyburide
Glipizide
Glimepiride

29
Q

Drugs under glinides

A

Megaglitinides
Repaglinides

Phenylalanine analogue
Nateglinides

30
Q

Sulfonylureas 1st generation drugs

A

Acetohexamide
Tolbutamide
Chlorpropamide

31
Q

Features of 2nd generation sulfonylureas
(4)

A

Glyburide or Glibenclamide :

It has an active metabolite. The drug gets concentrated in the ẞ islet cells and thus is longer acting than its half-life (T). OD dosing is sufficient.

Glimepiride: Sulfonylurea with least dose requirement to induce

hypoglycemia.

Gliclazide:

It has an additional antiaggregant effect.

Glipizide:

short acting. Lesser risk of hypoglycemia, hence preferred in elderly patients.

32
Q

Which guanide was banned ?

A

Phenformin due to severe lactic acidosis

33
Q

Drug of choice for treatment of DM 2

A

Metformin

34
Q

Drug of choice for ptophylaxis in pre-diabetics

A

Metformin

35
Q

Which drug is banned in USA and comes with black box warning in India

A

Piloglitazone

36
Q

SGLT 2 inhibitors
Glifozin

A

Cana
Dapa
Empa
Ertu

37
Q

Group of Drug of choice for Secretory Diarrhea

A

Somatostatin Analogues

38
Q

Drug group of choice in Tumors like
Glucagonoma

• VIPoma

• GRFoma.

• Somatostatinoma

A

Somatostatin Analoguee

39
Q

Drug of choice in variceal bleeding

A

Terlipressin

40
Q

Features of Somatostatin
Location

A

LOCATION: Intestine, Stomach, Pancreas, Hypothalamus
2.INHIBIT:
Gastrin
Insulin
Glucagon
Growth Hormone

41
Q

Gonadotropins names
1.hMG
2. FSH
3.LH

A

MENOTROPIN

Urofollitropin
Folliotropin a &B.

HCG
Choriogonadotropin alpha

42
Q

Which androgen anatagonist aling with goserelin depot is used for prostate carcinoma

A

Bicalutamide

43
Q

GNRH agonists and analogues

A

Gonadorelin
Leuprolide
Goserelin
Nafarelin
Buserelin
Triptorelin

44
Q

GNRH antagonists

A

Cetorelix
Ganirelix
Elagolix
Abarelix

45
Q

Which should be always given along estrogen to reduce risk of endometrial carcinoma

A

Progestogen

46
Q

In which condition can estrogen be used alone

A

Hysterectomy

47
Q

HT have substantially less estrogen than contraceptipn

A

True

48
Q

Which drug is a 19-nonsteroid used for HRT and its metabolite have estrogenic, progestrogenic and androgenic properties

A

Tibolone

49
Q

Most potent bisphpsphanates

A

Zoledronate

50
Q

Which drug is drug of choice for osteoporosis

A

Bisphosphonates

51
Q

Which drug is drug of choice for hypercalcemia of malignancy

A

Bisphosphonates

52
Q

Which drug is drug of choice for pagets’ disease

A

Bisphosphonates

Pharmacology (20 decks)

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