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Pharmacology > Autonomic Nervous System-SNS > Flashcards

Autonomic Nervous System-SNS Flashcards

1
Q

Which drug is a competitive inhibitor of tyrosine in synthesis of NE

A

Metyrosine

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2
Q

Drugs which are VMAT 2 Blockers

A

Reserpine
Tetrabenazine
Deutetrabenazine
Valbenazine

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3
Q

Which drug is used in pre-operative hypertension if alpha blocker followed by beta blocker therapy is contraindicated like in Heart failure

A

Metyrosine

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4
Q

Which drug is used in malignant pheochromocytoma where surgery is contraindicated

A

Metyrosine

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5
Q

Which drug is used in mild to moderate HTN and agitated psychotic state

A

Reserpine

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6
Q

Which two drugs are drug of choice for Huntington’s Chorea

A

Tetrabenazine and Deutetrabenazine

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7
Q

Which two drugs are used for tics treatment in Tourette syndrome

A

Tetrabenazine and Deutetrabenazine

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8
Q

Which two drugs are drug of choice for treatment of Tardive Dyskinssia

A

Deutetrabenazine and Valbenazine

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9
Q

Which three drugs are blocker of re-uptake of NE and Dopamine

A

Tricyclic antidepressent like imipramine
SNRI such as Duloxetine
Cocaine

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10
Q

Which is drug of choice for cocaine dependance is also D receptor agonists

A

Bromocriptine

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11
Q

Which drug is drug of choice in vasodilatory shock and cardiogenic shock

A

NE

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12
Q

Which drug is given only Intravenously and not I/m due to its vasoconstrictor effect

A

NE

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13
Q

Which Is drug of choice in cardiac arrest

A

Epinephrine

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14
Q

Which Is drug of choice in Anaphylactic Shock

A

Epinephrine

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15
Q

Which drug is used as local vasoconstrictor to decrease bleeding

A

Epinephrine

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16
Q

Which drug is given in combination with local anesthetic to increase the duration of action and decrease the toxicity of local anesthetic

A

Epinephrine

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17
Q

Which drug is used in open angle glaucoma as they decrease aqueous humor production and increase uveoscleral outflow

A

Epinephrine and prodrug dipivefrine

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18
Q

Which drug is used in epistaxis as nasal packs soaked in diluted form

A

Epinephrine

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19
Q

Which drug dose must be regulated in hyperthyroidism as it has increased production of adrenergic receptors

A

Epinephrine

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20
Q

Which drug is given in acute congestive heart failure with oliguria

A

Dobutamine with furosemide (not dopamine)

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21
Q

Which catecholamine is first choice drug in shock and refractory heart failure

A

Dopamine

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22
Q

Which drug causes tissue necrosis if given as Im injection

A

NE

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23
Q

Which drug causes tachycardia if atropine blocks the vagal effects or a transplanted heart and shows the former drug’s positive ionotropic effect which is increased heart rate

A

NE

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24
Q

Which drug is inotrope of choice in acute congestive heart failure

A

Dobutamine

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25
Q

Which drug is given in stress cardiography in patients who are unable to exercise

A

Dobutamine

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26
Q

Which drug can be used for acute CHF, cardiogenic shock, bradycardia, torsades and conduction block

A

Isoprenaline

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27
Q

Which drug can be used for bronchospasm in anesthesia

A

Isoprenaline

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28
Q

Which drug is used in neurogenic hypotension in Diabetic neuropathy

A

Droxidopa

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29
Q

Which two drug causes diuresis and decrease BP

A

Fenoldopam and Dopexamine

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30
Q

Which is also an alpha 2 agonist used in hypertensive emergency iv

A

Fenoldopam

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31
Q

Which is also a beta 2 agonist used in acute congestive heart failure

A

Dopexamine

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32
Q

Which catecholamine increase force of contraction of heart but decreases rate of contraction of heart

A

NE

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33
Q

Which drug is a drug of choice for priapism, spinal anesthesia induced hypotension without bradycardia

A

Phenylephrine

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34
Q

Which is used only as nasal decongestant (topical)

A

Xylometazoline

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35
Q

Which is drug of choice for postural hypotension

A

Midodrine

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36
Q

Which drugs are used to treat hypotension

A

Mephentermine
Metraraminol
Methoxamine

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37
Q

Which is drug of choice in hypertensive urgency

A

Clonidine

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38
Q

Which drug can be used to treat ADHD, Postmenopausal hot flashes, diarrhea in Diabetes Mellitus

A

Clonidine

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39
Q

Which drug can be used in opoids/smoking/alcohol dependence and is a pre-anesthetic medication

A

Clonidine

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40
Q

Which alpha 2 agonists is used as a pre-anesthetic medication and causes sedation, analgesia and also decreases secretions

A

Dexmedetomidine

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41
Q

Which drug is not used for induction of anesthesia due to requirement of high dose due to high risk of hypotension

A

Dexmedetomidine

42
Q

Which drug is used as muscle relaxant

A

Tizanidine

43
Q

Which drug is approved for opoid dependance

A

Lofexidine

44
Q

Which drug is used in treatment of pregnancy induced hypertension

A

Lofexidine

45
Q

Which drug is drug of choice in pregnancy induced hypertension

A

Labetalol

46
Q

Which drugs are drug of choice for mild tics in Tourette syndrome

A

Guanfacine and clonidine

47
Q

Which drugs are used in treatment of ADHD

A

Guanabenz and Guanfacine

48
Q

Which drug is preffered in Tourette syndrome treatment of tics

A

Guanfacine

49
Q

Which drug is drug of choice when tics are severe in Tourette syndrome

A

Atypical antipsychotics
(Also tetrabenazine)

50
Q

Which drugs are used to treat open angle glaucoma as they decrease aqueous humor production and increase uveoscleral outflow

A

Apraclonidine and Bromindine

51
Q

Which drugs which are imidazoline receptor agonist and also alpha 2 agonists are used in resistant HTN and neuropathic pain

A

Moxonidine and Rilmonidine

52
Q

Which drugs are beta 3 agonists and used for urge incontinence or overactive bladder

A

Mirabegron
Vibegron

53
Q

Which drugs are fast acting beta 2 agonists used in acute attack of bronchial asthma

A

Salbutamol
Terbutalone
Pirbuterol
Formoterol

54
Q

Which drugs can be used in persistent bronchial asthma as bd dosing along with corticosteroids
It is also a prophylaxis of asthma

A

Salmeterol
Formoterol

55
Q

Which drugs are add on to anticholinergics in COPD

A

Salmeterol
Formeterol

56
Q

Which drugs can be used for only COPD treatment (long term management)

These are VLABA

A

Olodaterol
Vilanterol
Carmoterol
Indacaterol

57
Q

Which drug is drug of choice when cheese reaction occur due to tyramine

A

Phentolamine (alpha blocker)

58
Q

Which drug is drug of choice in ADHD

A

Methylphenidate

59
Q

Which drug should not be used in ADHD with Tourette syndrome or family history of drug abuse potential

A

Methylphenidate

60
Q

Which indirect acting sympathomimetic is used in narcolepsy

A

Methylphenidate

61
Q

Which drug is drug of choice in Nacrolepsy

A

Modafinil

62
Q

Which drug is drug of choice in excessive sleepiness or Obstructive sleep apnea or shift worker disease

A

Modafinil

63
Q

Which other drugs are also used for nacrolepsy

A

Pitolisant (H3 receptor blocker)
Solriamfetol (DNRI)

64
Q

Which drug is a stimulant used in ADHD, narcolepsy and obesity

A

Amphetamine

65
Q

Which drug is a designer drug and is also drug of abuse

A

Methamphetamine or Crystal meth

66
Q

Which drugs is used for treatment of HTN (continuous dose) but contraindicated for pheochromocytoma patients since it precipitates HTN crisis

A

Guanethidine and Guanadrel

67
Q

Which drug is used in Spinal anesthesia induced hypotension and preffered with associated bradycardia

A

Ephedrine

68
Q

Which drug is a mixed sympathomimetic drug used as mydriatic and nasal decongestant (topical route)

A

Ephedrine

69
Q

Which drug is used as oral nasal decongestant

A

Pseudoephedrine

70
Q

Which drug was earlier used for treatment of obesity but now is banned due to high risk of stroke

A

Norephedrine or Phenylpropanolamine

71
Q

Which form of drugs are contraindicated in diabetic patients

A

Beta blockers

72
Q

Which drug type should not be given in patient with pheochromocytoma which has Epinephrine producing tumor since it can cause shock

A

Alpha blockers

73
Q

Alpha blockers can be given to pheochromocytoma patients with tumors producing?

A

NE

74
Q

Which indirect acting sympathomimetic can cause palatine perforation on large quantities

A

Cocaine

75
Q

Which drugs acting on beta 2 receptors are used for tocolytic effect on pre-term labour

A

Ritodrine
Isoxsuprine

76
Q

Which alpha 2 agonist is used that decreases central Sympathetic outflow, vascular resistance without decreasing cardiac output and used in gestational hypertension

A

Methyldopa

77
Q

Which drug is not preffered over salbutamol in asthmatic patient due to non beta selectivity which can cause beta 1 action also

A

Adrenaline

78
Q

Which drug is drug of choice in clonidine withdrawal HTN, intraoperative HTN in pheochromocytoma

A

Phentolamine

79
Q

Which is drug of choice for erectile dysfunction

A

Sildenafil

80
Q

Which is drug of choice for preoperative HTN in pheochromocytoma

A

Phenoxybenzamine

81
Q

Which drug is drug of choice in patient with both HTN and BPH

A

Terazosin
Doxazosin
Prazosin

82
Q

Which drug is drug of choice in scorpion bite induced pulmonary edema and hypertension

A

Prazosin

83
Q

Other drugs used in scorpion bite for seizures and bradycardia

A

Diazepam and Atropine

84
Q

Side effects are maximum in which selective alpha blocker

A

Silodosin

85
Q

Which alpha 1a blockers are drug of choice in isolated BPH

A

Tamsulosin
Silodosin

86
Q

Which type of drugs are drug of choice in migraine prophylaxis and essential tremor

A

Beta blockers

87
Q

Which drug form is drug of choice is aortic dissection with HTN

A

Beta blockers

88
Q

Which drug is preffered in bronchial asthma/COPD and is cardioselective

A

Betaxolol

89
Q

Most cardioselective beta blocker is

A

Nebivolol

90
Q

2nd most cardioselective beta blocker is

A

Bisoprolol

91
Q

Beta blocker with anti-oxidant effects and is cardioselective

A

Nebivolol

92
Q

Beta blocker with anti-inflammatory, anti-oxidant, alpha blocker and calcium channel blocker effect which is non-selective is

A

Carvedilol

93
Q

Which kind of beta blockers are contraindicated in MI and Migrane

A

Partial agonist beta blockers
(CLAP)

94
Q

Which kind of beta blockers are contraindicated indicated in Renal failure

A

Water Soluble beta blockers
(BANANAS Chips)

95
Q

Which beta blockers have maximum and minimum half life

A

Nadalol
Esmolol

96
Q

Which beta blockers have maximum and minimum PPB

A

Carvedilol
Celiprolol

97
Q

Which beta blockers have maximum and minimum bioavailablity

A

Penbutolol, Pindolol
Carvedilol, Propanolol

98
Q

Which is drug of choice in ulcerated infantile hemiangioma

A

Propranolol

99
Q

Which drug is used for all tremors except parkinsonism

A

Propranolol

100
Q

Which alpha 2 agonist attenuated various vasomotor symptoms of menopausal syndrome

A

Clonidine

101
Q

Which alpha 2 agonists controls loose motions due to diabetic neuropathy?

A

Clonidine

Pharmacology (20 decks)

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