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Pharmacology > Central Nervous System > Flashcards

Central Nervous System Flashcards

1
Q

Z drugs are used for

A

Insomnia

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2
Q

Drugs which belong to to 1st type of drugs based on metabolism
I: CYP3A4
II: Glucuronid action

A

Diazepam
Clorezepam
Chlordiazepoxide
Quazepam
Flurazepam

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3
Q

2nd type of drugs according to metabolism in which
I: CYP3A4
II: Faster Glucuronidation

A

Triazolam
Midazolam

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4
Q

3rd type of drugs according to metabolism
II: Direct Glucuronidation

A

Lorazepam
Temazepam
Oxazepam
Estazolam

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5
Q

Anti-epileptic drugs

A

Lorazepam
Diazepam

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6
Q

Drug of choice for status epilepticus

A

Lorazepam

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7
Q

Drug used to treat Juvenile myoclonic seizure
Absence seizure
Infantile spasm

A

Clonazepam

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8
Q

Drugs used to treat partial seizure

A

Clorazepate

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9
Q

Drug used to treat Lennox Gastaut syndrome and Dravet syndrome
Febrile seizures

A

Clobazam

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10
Q

BZDs used intranasal to treat acute repetitive seizure, crescendo seizure

A

Clonazepam
Midazolam

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11
Q

Drug of choice for treatment and prophylaxis of febrile seizures at home

A

Rectal Diazepam

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12
Q

Drugs (BZD) used for Insomnia

A

Quazepam
Flurazepam
Estazolam
Temazepam
Triazolam

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13
Q

Drugs (BZD) used for anxiety treatment are

A

Diazepam
Clorazepate
Chlorodiazepoxide
Alprazolam

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14
Q

Drug used to treat anxiety which given night before surgery

A

Alprazolam

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15
Q

Which drug (BZD) used for muscle relaxant

A

Diazepam

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16
Q

Which drug (BZD) is used for giving analgesia intrathecally

A

Midazolam

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17
Q

Which BZDs are used for alcohol and withdrawal symptoms

A

Diazepam
Clorazepate
Chlordiazepoxide

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18
Q

Which drug is preffered for alcohol and withdrawal symptoms if patient has seizures

A

Diazepam

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19
Q

Which drug (BZD) is preferred for alcohol and withdrawal symptoms

A

Chlordiazepoxide

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20
Q

Which tasteless drug is used as date rape drug
(It is also mixed with beer)

A

Flunitrazepam

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21
Q

Which drug (BZD) is used by drug abusers and also known as roofie

A

Flunitrazepam

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22
Q

Which BZD inverse agonists inhibit GABA action and are convulsants

A

Dimethoxy-ethyl-carbomethoxy-beta-carboline (DMCM)

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23
Q

Which drug BZD-antagonist blocks sedative action of BZDs as well as the convulsant action of DMCM

A

Flumazenil

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24
Q

Which drug type is used in treating spasticity from multiple sclerosis and cerebral palsy

A

BZD

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25
Q

Which drug (BZD) also gave analgesic effect on IV use

A

Diazepam

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26
Q

Which drug is given I.V. in Status Epilepticus

A

Lorazepam

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27
Q

Which drug (BZD) prevent stress ulcers

A

Diazepam

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28
Q

Which drugs (BZD) have no active metabolites

A

Lorazepam
Estazolam
Oxazepam

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29
Q

Which drug (Barb) is drug of choice for treatment of seizures in neonates

A

Phenobarbital

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30
Q

Which drug is drug of choice for Crigler-Najjar Syndrome type II

A

Phenobarbital

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31
Q

Which melatonin agonist is used for sleep induction and jet lag

A

Ramelteon

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32
Q

Which melatonin agonist is used for treatment of resistant depression

A

Agomelatine

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33
Q

Which melatonin agonists is used to treat sleep awake disorder in blind people

A

Tasimelton

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34
Q

Which melatonin agonists is used in treatment of paradoxical seizures caused by BZDs or Barbiturates

A

Chloral Hydrate

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35
Q

Which drug is drug of abuse used to make Mickey Finn cocktail where it is known as knock out drops

A

Chloral hydrate

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36
Q

Which drugs is a prodrug of meprobamate is used as a muscle relaxant and as an anxiolytic

A

Carisprodol

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37
Q

Which drug (BZD) has residual effects and culminates leading to ingestion peaking after 3-5 days. It is suitable for patients who have frequent nocturnal awakenings, but not for the elderly due to risk of next day sedation, ataxia and mental confusion

A

Flurazepam

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38
Q

Which drug (BZD) is broad spectrum for anxiolytic, muscle relaxant, premedicant, anesthetic and for emergency control of seizures. It is used for sleep maintenance and has less likely rebound insomnia on discontinuation

A

Diazepam

39
Q

The drug (BZD) used for anxiety disorders and night-time hypnotic
It has marked withdrawal phenomena after regular use

A

Alprazolam

40
Q

Which type of drugs are contraindicated in patients of sleep apnoe and COPD as it aggravates the situation

A

All hypnotics

41
Q

Which drug is calming amnesic analgesic used in electrical cardioversion of arrhythmias, cardiac catherization, endoscopic in obstetrics

A

Diazepam

42
Q

Which is the preferred ultra-short acting Barbiturate used as intravenous anesthetic agent used for induction or maintenance

A

Thiopentone

43
Q

Which ultra-short acting Barbiturate is used in electroconvulsive therapy

A

Methohexital

44
Q

Name the drugs which are short acting Barbiturates used as pre-anesthetic medication

A

Butobarbital
Secobarbital
Pentobarbital

45
Q

Which drug which is a Barbiturate used as third line drug in status epilepticus

A

Phenobarbital

46
Q

Name the drugs preferred to BZD for treating insomnias

A

Z-drugs
Zolpidem
Zaleplon
Zopiclone
Eszopiclone

47
Q

Which drug type is first line for jet lag and sleep induction in elderly people

A

Melatonin Agonists

48
Q

Which new type of drugs are being used for sleep maintenance

A

Dual orexin receptor antagonists (DORAs)

49
Q

Name drugs which are DORA used in sleep maintenance

A

Suvorexant
Daridorexant
Lemborexant

50
Q

Melatonin agonists which are contraindicated in younger patients since they lead to galactorrhea, infertility and amenorrhea due to increased prolactin than LH

A

Tasimelton
Ramelteon

51
Q

Which is the shortest acting benzodiazepine

A

Remimazolam

52
Q

Drug of choice for insomnia in blind people is

A

Tasimelteon

53
Q

Which general anaesthetic selectively inhibits excitatory NMDA receptors

A

Ketamine

54
Q

Malignant hyperthermia is a rare complication of use of the following anaesthetic:

A

Halothane

55
Q

Which type of drugs are listed in Beers List for medications to avoid in elderly due to dizziness, postural instability, ataxia and falls

A

Z-drugs

56
Q

Which drug is drug of choice in hyperprolactinemia in planning pregnancy

A

Bromocriptine

57
Q

Which drug is drug of choice in hyperprolactinemia

A

Pergolide
Cabergoline

58
Q

Which type of drug is drug of choice for compulsive behaviour like gambling

A

Non-Ergot Alkaloids

59
Q

Which drug is drug of choice for suicidal tendency in case of psychosis

A

Clozapine

60
Q

Which drug is drug of choice for suicidal tendency in case of mania or depression

A

Lithium

61
Q

Which is treatment of choice for suicidal tendency

A

Electroconvulsive therapy

62
Q

Which anti-psychotic causes QT prolongation maximum

A

Ziprasidone

63
Q

Which anti-psychotic causes QT prolongation minimum

A

Sertindol

64
Q

Which drug is drug of choice for levodopa induced psychosis

A

Pimavanserin

65
Q

Which drug in Atypical anti-psychotics is most potent D2 blocker

A

Risperidone

66
Q

Which drug in atypical anti-psychotics are least potent D2 blocker

A

Clozapine

67
Q

Which drug in atypical anti-psychotics are least potent other receptor blocker

A

Risperidone

68
Q

Which drug in atypical anti-psychotics are most potent other receptor blocker

A

Clozapine

69
Q

Which type of anti-psychotics do not have other receptor side effects and weight gain

A

Third generation
Aripiprazole
Brexipiprazole
Cariprazine

70
Q

Which drugs are drug of choice for tardiness dyskinesia

A

Valbenazine
Deutetrabenazine

71
Q

Which drug is drug of choice for Neuroleptic Malignant Syndrome

A

Dantrolene

72
Q

Which Kappa receptor agonist has been approved for anti-pruritic effect With chronic kidney disease patients on dialysis

A

Difelikefalin

73
Q

Which semi-synthetic opoid has been used for GIT, Urethra and Biliary spasm

A

Papaverine

74
Q

Which drug is drug of choice for prophylaxis of mania

A

Lithium

75
Q

Which type of drugs are drug of choice in acute mania

A

Atypical Antipsychotics

76
Q

Which drug is drug of choice in BPD

A

Lithium

77
Q

Which type of drug and preferred drug for mania in pregnancy

A

Atypical Anti-psychotics
Apiprazole

78
Q

Which drug is drug of choice for TCA toxicity

A

Sodium Bicarbonate

79
Q

Which two novel drugs are used in resistant Depression but do not cause erectile dysfunction

A

Vortioxetine
Vilazodone

80
Q

Which drug is drug of choice for partial seizure

A

Carbamazepine

81
Q

Which drug is drug of choice for Generalised seizures in CCB

A

Sodium Valoproate

82
Q

Which drug worsens JME

A

Phenytoin and Carbamazepine

83
Q

Which drug is drug of choice of GTCS

A

Valproate

84
Q

Which drug is drug of choice of JME

A

Valproate

85
Q

Which drug is drug of choice for Dravet Syndrome

A

Valproate

86
Q

Which drug is drug of choice for rapid cyclers

A

Valproate

87
Q

Which drug is drug of choice of Lennox-Gastaut syndrome

A

Valproate

88
Q

Which drug is drug of choice for atypical absence seizures

A

Valproate

89
Q

Which drug in epilepsy is most teratogenic

A

Valproate

90
Q

Which drug is drug of choice for typical absence seizure

A

Ethosuximide

91
Q

Which drug is drug of choice in partial seizures

A

Carbamazepine

92
Q

Which drug is drug of choice in trigeminal neuralgia

A

Carbamazepine

93
Q

Which drug of epilepsy is most preferred for migraine prophylaxis

A

Topiramate

Pharmacology (20 decks)

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