Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Autonomic Nervous System-PNS > Flashcards

Autonomic Nervous System-PNS Flashcards

1
Q

Choline reuptake inhibitor

A

Hemicholinum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Prevent entry of acetylcholine into vesicle inside the presynaptic neuron

A

Vesamicol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Antibiotics which block Ca+2 channel leading to blockage of Ach release on presynaptic neuron causing neuromuscular toxicity and worsening of myasthenia gravis

A

Aminoglycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If neuromuscular toxicity caused by Aminoglycosides then treatment method is

A

Calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which two drugs directly block the release of Acetylcholine from presynaptic neuron

A

Beta-Bungarotoxin
Botulinum toxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

M1 agonist used in the treatment of Alzheimer’s disease

A

Taclifensin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Whose venom causes release of Ach

A

Spider

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

A nonselective muscarinic agonist used to treat xerostomia and glaucoma

A

Pilocarpine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Since Nm and Nn receptors are different which drug blocks the Nm receptors?

A

Tubocurarine and Atracurium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name two drugs are used to block the Nn receptors?

A

Hexamethonium and Mecylamaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Indirect acting anti-cholinergic examples (3)

A

Aminoglycosides
Beta-Bungarotoxin
Botulinum toxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Direct acting cholinergic drug used in atonic bladder

A

Bethanechol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Direct acting cholinergic drug used in tachyarrythmia which acts on myocardium

A

Methacholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Direct acting cholinergic drug used for closed angle glaucoma acting on pupil

A

Pilocarpine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Directly acting cholinergic drug used in Sicca or Sjorgen syndrome and xerostomia which acts on gland secretion

A

Cevimeline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Drug of choice in closed angle glaucoma is

A

Pilocarpine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

4 examples of miotic agents

A

Pilocarpine
Physostigmine
Echothiphate
Fluostigmine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which drugs used as miotic agents and are also ACHE inhibitors which have a side effect of forming cataract while pilocarpine doesn’t ?

A

Physostigmine
Echothiphate
Fluostigmine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which type of drugs have common side effects such as accommodation spasm, brow ache, retinal detachment

A

Miotic agents
(Due to increase Ca level in muscles of accomadation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which drug is used as topical mitotic agent in ocular surgery

A

Acetylcholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Shortest acting beta blocker metabolised by pseusocholinestrase

A

Esmolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Shortest acting muscle relaxant metabolised by psuedocholinstrase

A

Succinyl Choline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Shortest acting opoids which are metabolised by psuedocholinesterase

A

Remifentanil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Shortest acting calcium channel blocker which are metabolised by pseudocholinesterase

A

Clevidipine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Which type of drugs are used to treat smoke dependence

A

Nicotinic agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Types of Muscuranic agonists which are Amines or Alkaloids

A

Pilocarpine
Cevimeline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Type of Muscuranic agonists which are Choline esters

A

Acetylcholine
Methacholine
Bethanechol
Carbachol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

3 drugs of direct acting nicotinic agonists

A

Nicotine
Varenicline
Cytisine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Which is a more effective drug than pilocarpine used in xerostomia

A

Cevimeline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Which drug is first line drug in an acute attack of closed angle glaucoma

A

IV Mannitol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Which drug is used to maintain normal IOP which is first decreased by IV Mannitol in case of acute attacke of closed angle glaucoma

A

Pilocarpine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Acetylcholine derivatives resistant to both ACHE and psuedocholinesterase

A

Bethanechol
Carbachol
Methacholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Which drug is used as mitotic agent in ocular surgery and closed angle glaucoma

A

Carbachol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Which drug is used in bronchial challenge test to diagnose bronchial asthma as it is short acting

A

Methacholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Which drug is used in gastroparesis and postoperative paralytic ileus

A

Bethanechol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

A direct acting cholinergic muscuranic agonists which acts majorly on M2 receptor

A

Methacholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

A direct acting muscuranic agonists and a choline ester is used because it acts on M3 receptor

A

Methacholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Irreversible indirect acting cholinergics

A

Organophosphates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Reversible direct acting cholinergics

A

Carbamates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Which drugs are ACHE activator which break phosphate bond of OPC which have not gone through ageing and have free anionic site

A

Oximes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Drug of choice in cholinergic poisioning

A

Atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

OPC drugs used in warfare agents (5)

A

Nerve gas such as
Sarin
Cyclotron
Tabun
Vc
Soman
DPF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Which indirect acting cholinergic drugs are OPC used clinically (2)

A

Echothiophate
Fluostigmine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Which OPC form commonly causes cholinergic poisoning

A

Insecticides and Pesticides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Which four drug form poisoning have common symptom of pinpoint pupil?

A

Opoid poisoning
Cholinergic poisoning (eg OP and Carbamate)
Phenol poisoning
Pontine Haemorrhage
Early Mushroom poisoning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Which drug form is more specific for OPC poisoning?

A

Oximes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Since atropine has only anti-muscuranic action so which drug form is used to relieve the nicotinic symptoms in cholinergic poisoning?

A

Oximes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

3 examples of oximes used in OPC poisoning

A

Pralidoxime
Obidoxime
Diacetyl mono oxime

49
Q

Which form of oxime is commonly used in India?

A

Pralidoxime

50
Q

Example of carbamates which are tertiary amines and can cross BBB

A

Physostigmine
Rivastigmine

51
Q

Tertiary Amines which are non-carbamates and can cross BBB

A

Galantamine
Tacrine
Donepezil

52
Q

Which drug is derived from calabar beans of planta physostigma venenosum

A

Physostigmine

53
Q

Which drug is drug of choice for anti-cholinergic poisoning

A

Physostigmine

54
Q

Which drug is used in treatment of closed angle glaucoma

A

Physostigmine

55
Q

3 types of anticholinergic poisoning

A

Atropine toxicity
Belladonna toxicity
Datura toxicity

56
Q

Which 4 drugs are used for treatment of Alzheimer’s disease since they are highly lipid soluble and majorly cross BBB without causing peripheral side effects

A

Rivastigmine
Galantamine
Tacrine
Donepezil

57
Q

Which is drug of choice for Alzheimer’s disease

A

Donepezil

58
Q

Drug form used in Myasthenia Gravis which block ACHE to increase ACh since it doesn’t cross BBB and act on periphery such as muscle

A

Quartenary Amines

59
Q

Which drug is short acting and used in diagnosis of MG (Tensilon test)

A

Edrophonium

60
Q

Which drug is used to differentiate MG and Cholinergic crisis

A

Edrophonium
1: improves
2: worsens

61
Q

Which drug is used in paroxysmal supraventricular tachycardia (PSVT) as it blocks AV node

A

Edrophonium

62
Q

Which drug is used in diagnosis and treatment if pyridostigmine is not present

A

Neostigmine

63
Q

Premedication with which drug is required while using edrophonium and neostigmine to avoid muscuranic side-effects?

A

Atropine

64
Q

Which drug us used in non-depolarizing muscle relaxant seen with atracurium, pancuronium

A

Neostigmine

65
Q

Which drug is used in Cobra bites since Cobra toxin damages NMJ causing respiratory paralysis

A

Neostigmine

66
Q

Which is drug of choice in generalised MG
It is oral and longer acting

A

Pyridostigmine

67
Q

Which drug form is given in pyridostigmine resistant patients

A

Steroids

68
Q

4 example of Immunosupressants given in patients of MG resistant to pyridostigmine and steroids

A

Mycophenolate Mofetil

Cyclosporine

Rituximab

Azathioprine

69
Q

Which is drug of choice in Myastheniac Crisis

A

Intravenous immunoglobulin (IVIG)

70
Q

Which is alternate treatment modality for Myasthenic Crisis

A

Plasmapheresis

71
Q

Which drug used to be a Drug of Choice for Alzheimer’s disease until we found alternative since it was hepatotoxic and short acting

A

Tacrine

72
Q

Which drug cannot be used for Alzheimer’s disease since it’s distribution in brain and periphery is 50% which is not effective even after crossing BBB?

A

Physostigmine

73
Q

Which drug is used in post-operative paralytic ileus and post-operative urinary retention which acts on M3 receptors?

A

Neostigmine

74
Q

Example of OPC drugs

A

Malathion
Parathion
Nerve gases forms

75
Q

Which drug cannot be given to overcome carbamate poisoning since carbamate form bond with both esteratic and anionic site

A

Oximes

76
Q

Which drug is used in Lambert Eaton syndrome as it blocks K+ channel which increase Ach release and increase muscle strength

A

Aminopyridines

77
Q

Drugs used for treatment of MG

A

Ambemonium
Neostigmine
Pyridostigmine

78
Q

Which anti-cholinergic drug which is a NM blocker is used for Tourette’s Syndrome?

A

Mecamylamaine

79
Q

Which drug is usd adjunct to nicotine in smoking depenede?

A

Mecamhlamaine

80
Q

Which anti-cholinergic drug used in hypertensive emergency intra-venously?

A

Trimethapan

81
Q

Which drug is used as K channel blockers for experiments

A

Tetraethylammoniun

82
Q

Which drug is known as the truth serum ?

A

Scopolamine

83
Q

Which drug is drug of choice in Narcoanalysis?

A

Thiopentone

84
Q

Which is the preffered cycloplegic in adults and is also shortest acting

A

Tropacamide

85
Q

Which drug is preffered cycloplegic in children

A

Atropine

86
Q

Which drug is an add on drug in fungal corneal ulcer

A

Atropine

87
Q

Drugs used in pupil which are muscuranic antagonists?

A

Tropacamide
Atropine
Cyclopentolate
Homatropine

88
Q

Which anti-cholinergic drug is a muscuranic antagonist, reduce secretions, is a preferred preanesthetic medication, doesn’t cross BBB and is a quartenary amine

A

Glycopyrrolate

89
Q

Drugs used to reduce oropharyngeal secretions?

A

Atropine
Glycopyrrolate

90
Q

Which drugs are DOC in COPD and add on drugs in bronchial asthma
These are muscuranic antagonists acting on lungs

A

Ipratropium
Oxitropium
Aclidinium
Glycopyrrolate
Umeclidinium
Revefenacin
Tiotropium

91
Q

Which drug is given with nebulizer in acute exacerbation of bronchial asthma

A

Ipratropium

92
Q

Which drug is drug of choice in COPD

A

LAMA which is Tiotropium

93
Q

Which drugs forms to be avoided in patients of BPH?

A

Muscuranic antagonists used in bladder

94
Q

Which drug is used in treatment of conduction blocks and digoxin toxicity

A

Atropine

95
Q

Which drug is drug of choice for bradycardia

A

Atropine

96
Q

At low doses which drug increase Ach which stimulate M2 receptors to causes further bradycardia

A

Atropine

97
Q

Name two drugs which are M1 blockers? And used in peptic ulcer syndrome

A

Pirenzepine
Telemzepine

98
Q

Which 3 drugs are anti-spasmodic?

A

Dicylomine
Glycopyrrolate
Scopolamine

99
Q

Which drug is drug of choice for motion sickness
(It is only for Prevention and not the Treatment)

A

Scopolamine

100
Q

Nonselective drugs which reduce detrusor contraction

A

Flavoxate
Oxybutynin
Fesoterodine
Trospium

101
Q

Which drug used in overactive bladder doesn’t cross BBB and is quaternary amine and not given to patients with renal failure as it is not excreted by liver

A

Trospium

102
Q

Name the selective M3 blocker used in bladder

A

Darifenavin
Solfenacin
Tolterodine

103
Q

A drug which is drug of choice for bradycardia and AV block

A

Atropine

104
Q

A drug which causes transient bradycardia since it blocks first pre-synaptic receptors but later blocks post-synaptic receptors which are M2 on heart leading to final result as tachycardia

A

Atropine

105
Q

Which drug is not given in cause of lungs and bronchus issue because it can’t be given through inhalation route and inhibits mucociliary clearance

A

Atropine

106
Q

A trick for drugs which are muscarinic antagonists used in overactive bladder etc.
(SOFT Bladder)

A

Solifenacin
Oxybutynin
Flavoxate
Fesoterodine
Tolterodine
Trospium
Darufenacin

107
Q

Which two drug are most vesico-selective (most block M3 receptor)

A

Solefenacin
Darifenacin

108
Q

Anti-cholinergics are drug of choice for Drug-induced Parkinsonism like

A

Benzhexol
Benztropine
Procyclidine

109
Q

Which drug is used for early mushroom poisoning caused by inocybe

A

Atropine

110
Q

Drug of choice for Belladonna and Datura poisoning is

A

Physostigmine

111
Q

Which drug is contradicted in Late mushroom poisoning caused by Amanita species

A

Atropine

112
Q

Which drug is used as an anti-spasmodic to reduce activity of GI tract

A

Atropine

113
Q

Which drug is used to measure refractive error without interference of accomodation capacity of eye

A

Atropine

114
Q

Which drug is preferred for pupillary dilation if cycloplegia is not required

A

Phenylephrine
(Alpha-adrenergic)

115
Q

Which 3 drugs are mainstay of medical therapy for OP poisoning

A

Atropine, Pralidoxime and benzodiazepines

116
Q

Which drug is used to treat poisoning with quartenary antimuscuranic poisoning

A

Neostigmine

117
Q

Which drug is used to treat post operative nausea and vomiting

A

Scopolamine

118
Q

Which type of drugs are used in nicotinic poisoning

A

Ganglionic Blockers

Pharmacology (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions