Sickle Cell Flashcards
1
Q
Pathophys
A
Pt mut beta globin chain glutamate to valine
Forms HbS which polymerises so rigid sickle shape
Short lifespan and trapped in vess
2
Q
Ethnicity
A
Comm in black, african, caribb
3
Q
4 syndromes
A
Sickle cell anaemia homoz
HbSC dis when other pt mut as well
Sickle b thalass mixture
Sickle trait heteroz
4
Q
Exacerbating factors
A
Cold
Dehyd
Low O tension
