Shelby Rudolph

Question 1

TNF-α increases neuron excitotoxicity through Ca-impermeable AMPA receptor channels.

Answer 1

F

Question 2

Neurons when exposed to TNF-α in combination with glutamate uptake blocker PDC show substantial degeneration.

Answer 2

T

Question 3

Calcium-permeable AMPA receptors are missing which Glu subunit?

Answer 3

Glu2

Question 4

Which molecule in excess causes neurodegeneration through excitotoxicity?

Answer 4

glutamate

Question 5

Prolonged TNF-α elevation potentiates slow excitotoxic motor neuron injury. Describe how this exposure acts and the mechanism at play in this excitotoxicity.

Answer 5

TNF-α present in elevated levels in combination with an excess of glutamate acts by increasing the concentration of calcium-permeable AMPA receptors on the membrane of motor neurons to enhance injurious excitotoxic effects of deficient astrocytic glutamate transport.