Jerome Link

Question 1

Duchenne Muscular Dystrophy is the most common type in adults.

Answer 1

F

Question 2

Defects in the dystrophin glycoprotein complex and the a7B31 integrin cause Duchenne Muscular Dystrophy.

Answer 2

T

Question 3

Duchenne Muscular Dystrophy effects

Answer 3

Only males

Question 4

Mice with an over expression of a7B31 protein…

Answer 4

b. Lived up to 64 weeks old, the duration of the experiment

Question 5

How is weight variable between mice with Duchenne Muscular Dystrophy and those treated with an over expression of a7B31? Name three other symptoms of DMD and what changes were studied in mice with the over-expression of a7B31.

Answer 5

Weight in mice with DMD decreases noticeably in the first 20 weeks of life. This leads to a lack of nutrients and decreased muscle strength. In mice with the a7B31 overly expressed protein, weight is maintained at a stable and normal level, however weight gain was not likely. 
Symptoms:
-Waddling gait
-Kyphosis
-Joint contractures
-Decreased Neruomuscular Junction folds
Change:
-hind legs retain function and gait is normal
-minimal to no spinal bending
-complete function and use of joints
-significantly increased number of folds