Marissa Bricker

Question 1

Chondroitinase improves autonomic function following a blunt SCI due to restoration of plasticity and regeneration

Answer 1

True

Question 2

Partially de-glycosilated CSPGs are less inhibitory to axon growth

Answer 2

True

Question 3

What are the concluded effects of Chondroitinase ABCI treatment?

Answer 3

inhibits an ECM proteogylcan

Question 4

Which is true regarding axon growth and CSPGs?

Answer 4

Axon growth can be stimulated via alternative pathways

Question 5

Give three critiques on the study on Chondroitinase ABCI and its effects on axon growth.

Answer 5

• Chondroitinase ABCI has inhibitory effects on CSPGs but also other growth promoting effects (researches recognized the existence of other ChABCI mechanisms)
• CSPGs bind nonspecifically so not positive exactly what mechanism was effected
• There are many different ways to inhibit axon growth that still remain when CSPGs are inhibited
• Results were not all statistically significant
• Could use better observation methods to yield better results
• Still need to examine adverse effects of treatment and reasons for ultimate death of rats usually, but not always, due to UTI
• Ongoing analyses of catheter scar
• Methods and controls done well and followed previous studies