Shades of Yellow Flashcards
Where does bilirubin come from
The breakdown of hemoglobin
Where does bilirubin live
The bile usually
What is conjugated bilirubin
Bilirubin + glucuronic acid
Gross appearance when there us excess bilirubin
yellow. mostly skin and mucous membranes
Pre-hepatic icterus is caused by…
Excessive bilirubin production due to increased hemolysis
Hepatic icterus is caused by…
Impaired uptake by hepatocytes or impaired conjugation
Post-hepatic icterus is caused by…
Impaired excretion - biliary obstriction (cholestasis)
What are carotenoids
exogenous pigments that are part of the diet
Carotenoids - gross appearance
Fat will appear yellow/orange
Not clinically significant
Abnormal accumulation of lipids is called…
lipidosis
lipidosis - gross
Organs are pale, yellow, and enlarged
Tissue feels greasy and may float
Hepatocytes enlarged w/ clear vacuoles
How do lipids accumulate in the liver
Excess delivery (absorption, carbs, mobilization)
Mitochondrial dysfunction (decreased oxidation)
Decreased transport
Decreased secretion of lipoproteins
