Seronegative Arthritis (Spondylarthritis) Flashcards
Where in the skeleton is Spondylarthritis normally present?
Axial skeleton (spine)
What are 2 common extra-articular features of spondylarthritis?
Uveitis and IBS
Seronegative arthritis is an umbrella term for different clinical presentations, what are 4 of these conditions?
Ankylosing spondylitis
Psoriatic arthritis
Bowel related arthritis (Crohns)
Reactive arthritis
What is Ankylosing Spondylitis (AS) ?
A chronic inflammatory rheumatic disorder which mainly occurs in the axial skeleton.
When is Ankylosing Spondylitis onset ?
2nd-3rd decade of life
There is a greater instance of AS in males or females ?
In males
What is the blood test which is +ve in ~90% of patient’s with AS?
HLA-B27
What is the criteria used for the diagnosis of AS, what is this comprised of?
NY Criteria
Based on clinical and radio-graphic findings
What are some of the important criteria when diagnosing AS?
Limitation of spinal movements - especially in anterior-anterior movement.
Limitation of chest expansion
Bilateral sacroiliitis on x-ray
How is sacroiliitis graded?
0-4
0- Normal
4- Severe abnormality or total ankylosis
What are the 2 stages at which AS can be detected?
Non-radiographic stage:
- Back pain
- Sacroiliitis on MRI
Radiographic stage:
- Back pain
- Radiographic sacroiliitis
- Back pain caused by syndemophytes
What are the recommended treatment for AS?
PT NSAIDs DMARD (Sulfasalazine) Anti-TNF Anti-IL-17
How does reactive arthritis occurs?
From sterile synovitis after a distant infection such as: Salmonella Shigella Campylobacter Chlamydia Neisseria
What is Reiter’s syndrome?
Arthritis
Urethritis
Conjunctivitis
How is reactive arthritis characterized?
Recurrent attacks which are common in chlamydia-induced arthritis.
