Multi-system Autoimmune Disease

Question 1

What is Systemic Lupus Erythematosus (SLE)?

Answer 1

An autoimmune disease where the body attacks healthy tissue.

It is a multi-system disease.

Question 2

What are some of the classic symptoms of SLE?

Answer 2

Malar rash (Butterfly rash)
Photo-sensitivity
Oral ulcers
Arthritis (2 joints at least)
Renal issues

Question 3

What is Scleroderma?

Answer 3

A group of autoimmune diseases.

Question 4

What are the 3 types of Scleroderma?

Answer 4

Morphea
Limited
Diffuse

Question 5

What is Sjogren’s Syndrome

Answer 5

Autoimmune disease characterized by dry eyes and dry mouth.

Question 6

What is autoimmune Myositis?

Answer 6

A rare autoimmune condition which is characterized by muscle weakness (symmetrical,diffuse or proximal)

Question 7

What is vasculitis?

Answer 7

An autoimmune disease affecting large, medium and small sized vessels.

Question 8

What are the diagnostic symptoms of Giant Cell Arteritis?

Answer 8

Age at onset >50y/o
New headache
Temporal artery tenderness/reduced pulsation
ESR >50
Abnormal temporal biopsy

Question 9

Name 3 forms of ANCA associated vasculitis

Answer 9

Granulomatosis with polyangitis (Wegners)

Microscopic polyangitis

Eosinophillic granulomatosis with polyangitis

Question 10

What are the characteristics of Granulomatosis with Polyangitis (Wegner’s) ?

Answer 10

Necrotising granulomatous inflammation.
Involves upper and lower resp. tract.
Affects small-medium vessels.
Necrotising glomerulonephritis is common.

Question 11

What are the characteristics of microscopic polyangitis?

Answer 11

Affects mainly small vessels.
Necrotising glomerulonephritis is v. common.
Pulmonary capillaritis often occurs.
Granulomatous inflammation is absent.

Question 12

What are the characteristics of Eosinophillic with polyangitis ?

Answer 12

Eosinophil rich and necrotising granulomatous inflammation occurs, often involving the resp. tract.
Mainly affects small-medium vessels.