Sepsis Flashcards
What is colonisation?
Presence of microbe i body without inflammatory response
What is an infection?
Inflammation due to a microbe
What is bacteraemia?
Presence of viable bacteria in the blood
What is sepsis?
Systemic inflammatory response to infection causing life-threatening organ dysfunction
What is septic shock?
Associated with cellular ü/- metabolic dysfunction
What are community causes of sepsis?
E. coli (urine abdomen)
S. pneumonia
S. aureus (usually MSSA - skin)
What are hospital causes of sepsis?
E. coli (urine abdomen) Staph aureus (MRSA - line/wound) CNS - coagulase negative strep (line/prosthetic) Enterococci - urine, wound, line Klebsiella - urine, wound Pseudomonas
How doe sepsis locally present?
Pain Tenderness Guarding Blood PR (some) Central crushing FAST score > 4 Absent bowel sounds (ileum) Oliguria Tachycardia Fever Hypotension Fluid balance change
What are systemic features of sepsis?
Fever, chills, rigors, nasuea/vomiting, costipation/diarrhoea, malaise, anorexia
What are signs of sepsis?
Decreased PaO2, decreased platelets, increased bilirubin
decreased MAP, increased GCS
Increased creatinine
SIRS can be confirmed if 2 or more of the following are present?
Temp <36 or >38
HR > 90
RR > 20
WCC <4 or > 12
Lines of investigation for sepsis?
Microbiology Microscopy Serology Antigen detection PCR Bloods
Blood findings for sepsis?
Increased WCC/CRP/Creatinine/PT/INR
Intraabdominal infection policy?
Amxocillin + Gentamicin + Metronidzole
Amoxicilin provides cover for?
Strep and enteroccocci
