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Gastrointestinal Conditions (JBR) > Fatty Liver Disease > Flashcards

Fatty Liver Disease Flashcards

1
Q

What does NAFLD stand for?

A

Non-acoholic fatty liver disease

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2
Q

What are the two types of NAFLD?

A

Increased fat in hepatocytes (steatosis) +/- inflammation (steatohepatitis)

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3
Q

What are risk factors for NAFLD?

A 
DM 
Dyslipidaemia
Parenteral feeding 
Jejuno-ileal bypass
Wilson's Disease
Drugs
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4
Q

Which drugs can cause NAFLD?

A

Amiodarone
Methotrexate
Tetracycline

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5
Q

What does the typical NAFLD patient look like?

A

Middle aged
Obese
Female

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6
Q

How do you investigate NAFLD?

A

LFTs - typically increased ALT
Fatty liver on USS
Biopsy may be needed

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7
Q

What are the outcomes of steatosis?

A

No liver outcomes

Increased CVS risk

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8
Q

How do you treat NAFLD?

A

Exercise and weight loss

?Bariatric surgery

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9
Q

How do you investigate NASH?

A

Liver biopsy

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10
Q

With NASH there is a risk of progression to?

A

Cirrhosis

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11
Q

What is methotrexate used for besides NAFLD?

A

RA and psoriasis

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12
Q

Methotrexate is a dose-dependent ___ liver and leads to progressive ______. There are no signs but you investigate by? Treat by?

A

liver
fibrosis
Monitoring fibrosis
Stop drugs

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13
Q

What is alcoholic liver disease?

A

Increased peripheral release of fatty acids, increased synthesis of fatty acids and triglycerides in liver cells

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14
Q

What is the pathophysiology of alcoholic liver disease?

A

Acetylaldehyde (alcohol metabolite) causes formation of Mallory’s hyalin - increase collagen synthesis by fibroblasts and perisinusoidal cells

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15
Q

2-3 day binge results n a?

A

Fatty liver (reversible)

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16
Q

What is the microscopic appearance of a liver after a 2-3 day binge?

A

Fat vacuoles appear clear in hepatocytes

17
Q

4-6 weeks of drinking results in?

A

Hepatitis (reversible)

18
Q

What is the microscopic appearance of a liver after 4-6 weeks?

A

Hepatocyte necrosis
Neutrophils
Mallory bodies
Pericellular fibrosis

19
Q

Months-years of drinking results in?

A

Fibrosis (irreversible

20
Q

What is the microscopic appearance of a liver after months-years of drinking?

A

Collagen layer down round cells

21
Q

Years of drinking results in?

A

Cirrhosis (irreversible)

22
Q

What is the microscopic appearance of cirrhotic liver?

A

Definitive bands of fibrosis separating regenerative nodules

23
Q

What is the macroscopic appearance of cirrhosis?

A

micro nodular fibrosis with abundant white scarring

24
Q

What are the possible outcomes from alcoholic liver disease?

A

Cirrhosis, portal hypertension, malnutrition, HCC, social disintegration

Gastrointestinal Conditions (JBR) (33 decks)

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