Sepsis

Question 1

What is sepsis defined as

Answer 1

The life threatening organ dysfunction due to the disregulation of the host cell activity

Question 2

What are the 3 phases that would effect the lungs

Answer 2

Exudative (the presence of the inflammation fluid)
Proliferation (the leaving of the cells to the outside area, they would then be used to fix the problem)
Fibrosis (the scarring of the lung walls, making it stiff and tough)

Question 3

What happens when there is damage to the endothelium lining

Answer 3

Responsible for the coagulative cells
There would then be coagulation and clots forming

Question 4

What is part of the sepsis 6

Answer 4

Take 6 give 6
Oxygen
Antibiotic
Fluids
Urine output levels
Blood culture
Lactate levels

Question 5

What is the news2 score? What would be a bad score

Answer 5

Would calculate if someone is septic
Would not want a score of 7 or more

Question 6

What would be needed if you have a news score of 5-6

Answer 6

Another risk factor
Lactate of more then 2mmol
Looking visibly bad or sick
Lack of activity and energy

Question 7

What is the NICE Score

Answer 7

Same as the news2 score
Would be used for children

Question 8

What is the % oxygen that should be maintained

Answer 8

A level above 92%
Preferably want to have 94-98%

Question 9

Why would the patient have a purpic rash

Answer 9

Would have the destruction of the endothelium of organs
This would then lead to clotting
The red marks would be the blood clots that would form

Question 10

What are he main mechanisms of injury for a patient w/ sepsis

Answer 10

Coagulation
Immunosupression
UTI
Apoptosis
Direct cytotoxicity
Hypoxic hypoxia (as sepsis would also effect the lungs and the respiratory system)

Question 11

What are the components of pulmonary dysfunction

Answer 11

Exudative
Proliferation
Fibrosis
Surfactant damages (due to the damage of the alveoli and the t2 pneumoncytes)
Increased respiration rate

Question 12

What are the components of cardiac dysfunction

Answer 12

Hypotension (majority of the fluid would have left the blood vessels)
Vasodilation (would then have the odema-exudate fluid would surround the tissues)

Question 13

What would the levels of glucose be in a blood culture of sepsis

Answer 13

Gluconeogenesis, glycogenlysis and the insulin release
They would be using the glucose to produce the energy

Question 14

What would you give if your not sure what cause d the sepsis infection

Answer 14

The broad spectrum antibiotics
E.g. meropenem