HIV Flashcards
What cells does the HIV retrovirus infect
The CD4+ cells
What are the components of the HIV cells
The gp120 and gp41 proteins
The co-receptors CCR5+CXCR4
Integrase
Reverse transcriptase
Protease
What do the co-receptors do
They would draw the cell inwards towards the host cell
What type of virus is HIV
A single stranded enveloped RNA virus
What would you use to diagnose HIV
CD4 cell count
The p24 capsid antigens and the GP41 antigens
The antibody’s for the P24 antigens (in the blood stream)
What types of cells would contain the t-helper (CD4)
Monocytes/macrophages
Dendritic cells
What does the integrase do
Would allow the viral dna attach to the host dna in the nucleus
Would then allow the production of the rna
And the viral proteins
At what number of CD4 cells would you be asymptomatic
About 500mm3
At what number of cells would a person get AIDS
Below 200mm3
What is mean by U=U
the person would test negative for HIV for 6 months
Would then have the non-transmissible HIV
Why would you use combination therapy
Just in case the virus mutates
In case it becomes resistant (less likely to be resistant or mutant agains many)
What are the drug targets for HIV
Integrase inhibitor
RT inhibitor
Protease inhibitor
Why are the nucleoside and non-nucleoside drugs
Nucleoside: stops the production of the 3 prime end
Non-nucleoside: weakens the DNA
What diseases can come from having HIV
Kaposi sarcoma (skin cancer)
Pneumonia
Oral candidiasis (mouth fungal infection)
