Immunocompromised Host Flashcards
What is the definition of the immunocompromised hosts
State in which the immune system is unable to respond appropriately and effectively
What is the defect for children under 6 months
T cells or phagocyte defect
What is the immunodeficiency defect for child 6 months to 5 years
The B cells and antibody or phagocyte defect
What is the defect for 5 years to the later life
B cell
Antibody
Complement or secondary deficiency
What is the difference between the primary and the secondary immune deficiency
Primary: congenital and the genetic
Secondary: acquired (from diseases)
What is Brutons disease
X-linked agammaglobulinaemia
No mature B cells
No production of the antibody’s
What is commmon variable immunodeficiency
The decrease in the protective antibodies
What is hyper IgM syndrome
Large amount of the immature IgM antibodies
No igG which would be needed
So would be immunodeficient
What is the deficiency in the igG2
IgG2 allow phagocytosis of the capsulated bacteria
When have the deficiency, would not allow the phagocytosis of the capsulated bacteria
What are immunodeficiency’s caused by the antibodies
The hyper IgM syndrome
Brutons disease
Common variable immunodeficiency
The deficient igG2
What are the immunodeficiency’s caused by the T cells
SCID (severe combined immunodeficiency)
The CD3 deficiency
The MHC1 AND MHC2
What is SCID
when would have the deficiency in the b and the T cells
So would have no adaptive immune system
What is the CD3 deficiency
No antigen presentation
So no interaction with the t and the B cells
Why is it bad to have the MHC1 deficiency
Would not have the self antigen presentation
So self tolerance would go down
What is chronic granulomatous disease
No oxygen burst
No antioxidant power
Bacteria cannot be broken
What is chediak-higashi syndrome
No fusion of the phagosome and the lysosome
Bacteria cannot be broken down
What are the factors that would make you suspect and immunodeficiency
S: SEVERE
P: PERSISTANT
U: UNUSUAL
R: RECURRENT
What can cause the secondary immune deficiencys
Malnutrition
HIV
Splenectomy
Liver disease
Why would malnutrition lead to the immune deficiency
Decreased amount of zinc
So would not allow the maturation of the B cells
What bacteria would be present when have a complement deficiency
Neisseria species
Streptococcus
Haemophilus influenza
What bacteria would be present when would have the phagocytic defects
Staphylococcus aureus
Pseudomonas
What bacteria would be present when would have the antibody deficiency
Streptococcus
Staphylococcus
Haemophilus influenza
What are the types of immunoglobulin replacement
IVIG (intravenous immunoglobulins)
ScIG (subcutaneous immunoglobulins)
What are the conditions that the immunoglobulin replacement would be used for
Brutons disease (no B cells made so would have no antibodies)
Hyper IgM (giving the igG most likely)
Common variable immunodeficiency (low level of the protective antibodies)
