Selective-Beta 2 Agonists

Question 1

When are selective B2 agonists selectivity lost?

Answer 1

High concentrations

Question 1

What are 2 pulmonary effects of B2-selective adrenergic receptor agonists?

Answer 1

1) Bronchodilation
2) Decreased airway inflammation (suppression of histamine/leukotrienes)

Question 2

Adverse effects of B2 selective adrenergic receptor?

Answer 2

Tremor, anxiety, tachy, arrhythmia, myocardial ischemia (increased in CAD or arrhythmia pt’s)

Patients taking MAO inhibitors are at higher risk of having these effects

Question 3

While Albuterol is a short-acting B2 agoninst, Salmeterol/Formoterol are _____

Answer 3

long-acting

Question 4

What type of onset of action does salmetrol have? Formoterol?

Answer 4

Salmetrol: Slow
Formoterol: Fast

Question 5

Clinical use of Albuteral?

Answer 5

Asthma (symptomatic relief of bronchospasm)

Question 6

Clinical use of Salmetrol and Formoterol?

Answer 6

COPD or nocturnal/persistent asthma

Question 7

Mirabegron is a selective ___ agonist that is used to treat __ __. To work, it relaxes the ___muscle of the bladder, increasing bladder capacity.

Answer 7

B3; urinary incontinence; detrusor

Question 8

Adverse side effects of Mirabegron?

Answer 8

1) HTN 2) UTI 3) Headache