Muscarinic Antagonists

Question 1

What are the 6 muscarinic antagonists?

Answer 1

Scopolamine
Atropine
Ipatropium
Dicyclomine
Tolteridine
Tropicamide

Question 2

Scopolamine treats ___ and ___ using a patch

Answer 2

vertigo; motion sickness

Question 3

What are the three uses of atropine?

Answer 3

1) Bradycardia
2) Organophos/Nerve Agent Poisoning
3) Pre-anasthesia

Question 4

Dicyclomine is used to treat ___ while Ipatropium is used to treat ____

Answer 4

IBS; Asthma/COPD

Question 5

Tolteridine is used to treat ___ while Tropicamide is used to ____ at eye doctor

Answer 5

Urinary incontinence; dilate pupil

Question 6

Of the muscarinic antagonist, which are quat and non?

Answer 6

Quat: Ipatropium
Non: Dicyclomine

Question 7

How do muscarinic antagonist affect the eyes? secreteions? Airways? CNS?

Answer 7

Eyes: Mydriasis, cycloplegia, increase IO pressure
Secretions: Dry
Airway: Bronchodilation
CNS: low doses (sedation/amnesia)
high doses (excitation/seizures)

Question 8

Six adverse side effects of muscarinic antagonists?

Answer 8

1) Dry mouth
2) Dry, hot skin
3) Constipation
4) Urinary retention
5) Visual disturbances/hallucinations
6) CNS effects (amnesia, confusion, sedation)

Question 9

Contraindications for muscarinic antagonists?

Answer 9

1) Glaucoma
2) Prostastic Hypertrophy
3) Cardiovascular Instability
4) Severe ulcerative colitis