Beta Agonists (Non-selective) Flashcards
___is a potent, non-selective beta agonist with a low affinity for alpha receptors
Isoproterenol
___ has two isomers. Both isomers are beta agonists.
Dobutamine
What effect does isoproterenol have on blood pressure?
MAP and Diastolic: Decrease
Systolic: -/Increase
How does dobutamine affect peripheral resistance? Why is this the case?
Minimal effect because there’s a counter balance of a1 receptor-mediated vasconstriction and b2 receptor-mediated vasodilation
How does isoproterenol affect respiration?
Bronchodilation
How does isoproterenol affect peripheral resistance and skeletal muscle vasculature?
Peripheral resistance: decreases
-Affects skeletal muscle vasculature
Adverse effects of isoproterenol? (4)
1) palps/tachy
2) headache
3) flushing
4) cardiac ischemia (agina) or arrhythmias
How does dobutamine affect HR, contractility, and CO?
Contractility/CO: Increase
HR: —
Adverse effects of dobutamine? (2)
1) Increase BP/HR
-hypertensive pts may have exaggerated pressor response
2) Ventricular Tachy (only those with AFIB are at high risk for this)
-due to facilitation of AV conduction
If a patient with AFib is given dobutamine and you are worried they will develops Ventricular Tachycardia, how can you try to prevent this?
Digoxin
Therapeutic uses of Isoproterenol?
Emergency stimulation of heart (bradycardia or heart block)
[However: Epinephrine and Dopamine are better for this]
Dobutamine can be used for short-term management of patients with cardiac decompensation. In what three conditions could this medication be provided?
1) s/p acute MI
2) CHF
3) s/p cardiac sx
True or False: Dobutamine has a more prominent chronotrophic effect than inotrophic effect
False
Dobutamine has a more prominent inotrophic effect than chronotrophic effect
