Indirect Acting Sympathomimetics

Question 1

___ inhibits reuptake of biogenic amines from synaptic cleft. It inhibits: DAT, SERT, and NET

Answer 1

Cocaine

Question 2

What are the five indirect acting sympathomimetics?

Answer 2

1) Cocaine
2) Amphetamine
3) Dextroamphetamine
4) Methamphetamine
5) Methylphenidate

Question 3

Therapeutic use of cocaine?

Answer 3

Topical anesthesia of upper respiratory GI
-local anesthesia + vasoconstrictor

Question 4

Adverse effects of cocaine? (5)

Answer 4

1) Aortic dissection
2) Myocarditis
3) Cardiac arrhythmia
4) Myocardial Ischemia
5) Cerebral Vasoconstriction

Question 5

What drug releases biogenic amines from storage vesicle in CNS/Peripheral Sympathetic Nerve Terminals and inhibits VMAT?

Answer 5

Amphetamine

Question 6

How do amphetamines affect HR and SP/DP?

Answer 6

HR: Reflexively decrease
Systolic/Diastolic: Increase

Question 7

Amphetamine, Dextroamphetamine, Methylphenidate, and Methamphetamine can treat what two disorders?

Answer 7

1) ADHD
2) Narcolepsy

Question 8

What drug is one of the most potent sympathomimetic amines?

Answer 8

Amphetamines

Question 9

____ is structurally similar to amphetamines, but is a mild CNS stimulate and has more prominent mental effects (not motor)

Answer 9

Methylphenidate

Question 10

How do methamphetamines affect BP?

Answer 10

Increase SD/DP

Question 11

How do dextro/methamphetamines affect CNS?

Answer 11

Affect CNS more than peripheral

Question 12

How do amphetamines affect urinary sphincter and GI?

Answer 12

GI = unpredictable response
Urinary Sphincter = contracts