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Pharmacology > NSAID's > Flashcards

NSAID's Flashcards

1
Q

True or False:
Diflunisal is an anti-pyritic agent

A

False

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2
Q

Which NSAID is good for treating dysmenorrhea?

A

Celecoxib

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3
Q

If you are trying to treat
RA or Osteoarthritis you can use NSAID except ___ and ___

A

ketorolac or mefenamic acid

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4
Q

What two drugs are indicated for treating juvenile RA?

A

Naproxen and Tolmetin

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5
Q

True or False:
You can treat juvenile RA with Indomethacin

A

False

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6
Q

Mechanism of action for Diflusinal vs. Aspirin?

A

Diflusinal: Reversible inhibition of COX-1/COX-2
Aspirin: Irreversible inhibition of COX-1 and -2

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7
Q

Misoprostol is a prostaglandin analogue with ____ effects, can be used for long term RA treatment

A

anti-ulcer effects

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8
Q

Nabumetone is activated by the ___

A

liver

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9
Q

Having tinnitus/hearing loss while taking aspirin indicates?

A

Chronic salicylate intoxication/salicylism

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10
Q

Aspirin is contraindicated in?

A

Hemophilia
vWB disease
Telangiectasia

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11
Q

What kids do not get aspirin? What can you use instead?

A

-Those with chicken pox/flu-like disease
-Puts them at higher risk of Reye’s Syndrome
-Use acetaminophen

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12
Q

Chronic NSAID use can cause:
1) Acute Renal Insufficiency
2) Interstitial nephritis
3) Hyperkalemia
4) Hypernatremia
5) Papillary Necrosis - irreversible

Mechanism?

A

Inhibition of renal prostaglandin (COX-2) synthesis

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13
Q

COX makes prostaglandins from ____

A

arachidonic acid

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14
Q

At low pH (stomach)aspirin is ____ while at a high pH (small intestine) it is ____ and dissolution occurs because absorption not limited because of large SA!)

A

non-ionized; ionized

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15
Q

How does changing pH of urine help get aspirin out of the body?

A

The more basic the urine, the greater the renal clearance

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16
Q

Why can tubular necrosis occur in patients taking aspirin?

A

Inhibition of renal prostaglandin synthesis (COX2) causes renal medullary ischemia

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17
Q

The urticaria or angioedema you can get while taking aspirin are a type ___ reaction associated with __

A

Type I, IgE

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18
Q

Aspirin sensitivity, asthma, nasal polyps, and bronchospasm describes ___ ___

A

Aspirin Triad

19
Q

You shouldn’t use aspirin in expecting mothers since there’s an association with congenital abnormalities and hemorrhaging, but its ok for ___

A

pre-eclampsia

20
Q

Anti-coags and ___, taking with aspirin can increase bleeding risk while ___ will increase renal clearance of aspirin

A

thrombolytic agents; corticosteroids

21
Q

Aspirin intoxication presentation in kids?

Steps?

A

Hyperventilation

1) CNS stimulation (salicylate lag)
2) CNS depression
(death, coma, respiratory failure)

22
Q

Acetaminophen is used to treat fevers bu acting on ____ heat regulating center

A

hypothalamic

23
Q

____, also known as paracetamol, ___inhibits COX1/2

A

Acetaminophen; weakly

24
Q

The small amount of acetaminophen metabolized by cytochrome P450 can form a toxic intermediate, which can damage __ and ___

A

liver; kidney

25
Q

____ is the specific antidote for acetaminophen toxicity

A

Oral N-acetylcysteine

26
Q

What two NSAID’s are associated with headache?

A

Indomethacin and ketorolac

27
Q

What NSAID is associated with headache and worsening depression?

A

Indomethacin

28
Q

Autoimmune hemolytic anemia - type ___ drug allergy is associated with use of what NSAID? Antibodies?

A

II; Tometin; IGG

29
Q

___ and ___ and ____ __ are not recommended for kids under 14 yoa (risk of hepatotoxicity)

A

Indomethacin, Mefenamic acid, and meclofenamate

30
Q

What two NSAID’s induces closure of the fetal ductus arteriosus via inhibition of prostaglandin E2?

A

Ibuprofen and Indomethacin

31
Q

How do you eliminate aspirin from system?

A

Alkalize the urine (IV sodium bicarbonate)

32
Q

When should you discontinue use of Aspirin if you have upcoming surgery?

A

5-7 days prior

33
Q

Post-op hematomas are common when __ is given IM

A

ketorolac

34
Q

How does oral N-acetylcysteine fix acetaminophen toxicity?

A

Restores glutathion levels

35
Q

__ is a good substitute for aspirin, but its anti-inflammatory effects are weaker

A

Acetaminophen

36
Q

Nephrotoxicity and hepatoxicity, as well as rash/allergic reaction is most worrisome for ____

A

acetaminophen

37
Q

___ should not be given to a patient who has has asthma, rash, or allergic-type reaction to sulfonamides, aspirin, or NSAID’s

A

Celecoxib

38
Q

Celecoxib inhibits ___

A

COX-2

39
Q

NSAID’s can prolong ___ and should be avoided in ___ trimester

A

labor; trimester

40
Q

____ necrosis is a irreversible type of renal injury associated with use of ___

A

Papillary; Difusinal

41
Q

What is the first choice for anti-inflammatory and analgesic effects in RA, JA, and OA treatment?

A

Aspirin

42
Q

Adult daily dosage range for aspirin?

A

2.4-3.6

43
Q

___ and ___ are most common signs of chronic aspirin intoxication in adults - could be accompanied by metabolic ___ and respiratory ___

A

tinnutis/hearing loss

acidosis; alkalosis

44
Q

Lethal dose of aspirin in kids? adults

A

4g; 10-30 g

Pharmacology (13 decks)

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