Alpha-1 Selective Agonists Flashcards
1
Q
Phenylephrine is a potent, direct acting ___ adrenergic agonist
A
alpha-1
2
Q
How does phenylephrine affect systolic and diastolic blood pressure?
A
Increases
3
Q
How does phenylephrine affect heart rate? Why?
A
Decrease (reflexive bradycardia)
4
Q
How does phenylephrine affect vasculature and blood flow?
A
Decreases blood flow, causes vasoconstriction
5
Q
What is the role of the compensatory autonomic baroreflex response in phenylephrine?
A
The response blunts the a1 agonist BP effects. Therefore: as HR increases, BP decreases and vice versa.
6
Q
Therapeutic uses of phenylephrine? (3)
A
1) Hypotension (orthostatic/shock)
2) Nasal decongestant
3) Ophthalmic agent
